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FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption.
Clifford BL, Sedgeman LR, Williams KJ, Morand P, Cheng A, Jarrett KE, Chan AP, Brearley-Sholto MC, Wahlström A, Ashby JW, Barshop W, Wohlschlegel J, Calkin AC, Liu Y, Thorell A, Meikle PJ, Drew BG, Mack JJ, Marschall HU, Tarling EJ, Edwards PA, de Aguiar Vallim TQ. Clifford BL, et al. Among authors: meikle pj. Cell Metab. 2021 Aug 3;33(8):1671-1684.e4. doi: 10.1016/j.cmet.2021.06.012. Epub 2021 Jul 15. Cell Metab. 2021. PMID: 34270928 Free PMC article.
An integrative systems genetic analysis of mammalian lipid metabolism.
Parker BL, Calkin AC, Seldin MM, Keating MF, Tarling EJ, Yang P, Moody SC, Liu Y, Zerenturk EJ, Needham EJ, Miller ML, Clifford BL, Morand P, Watt MJ, Meex RCR, Peng KY, Lee R, Jayawardana K, Pan C, Mellett NA, Weir JM, Lazarus R, Lusis AJ, Meikle PJ, James DE, de Aguiar Vallim TQ, Drew BG. Parker BL, et al. Among authors: meikle pj. Nature. 2019 Mar;567(7747):187-193. doi: 10.1038/s41586-019-0984-y. Epub 2019 Feb 27. Nature. 2019. PMID: 30814737 Free PMC article.
Relationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer's Disease.
Lim WLF, Huynh K, Chatterjee P, Martins I, Jayawardana KS, Giles C, Mellett NA, Laws SM, Bush AI, Rowe CC, Villemagne VL, Ames D, Drew BG, Masters CL, Meikle PJ, Martins RN; AIBL research group. Lim WLF, et al. Among authors: meikle pj. J Alzheimers Dis. 2020;76(1):303-315. doi: 10.3233/JAD-191304. J Alzheimers Dis. 2020. PMID: 32474467 Free PMC article.
Reducing hepatic PKD activity lowers circulating VLDL cholesterol.
Genders AJ, Connor T, Morrison S, Bond ST, Drew BG, Meikle PJ, Howlett KF, McGee SL. Genders AJ, et al. Among authors: meikle pj. J Endocrinol. 2020 Sep;246(3):265-276. doi: 10.1530/JOE-19-0548. J Endocrinol. 2020. PMID: 32698129
Fructose stimulated de novo lipogenesis is promoted by inflammation.
Todoric J, Di Caro G, Reibe S, Henstridge DC, Green CR, Vrbanac A, Ceteci F, Conche C, McNulty R, Shalapour S, Taniguchi K, Meikle PJ, Watrous JD, Moranchel R, Najhawan M, Jain M, Liu X, Kisseleva T, Diaz-Meco MT, Moscat J, Knight R, Greten FR, Lau LF, Metallo CM, Febbraio MA, Karin M. Todoric J, et al. Among authors: meikle pj. Nat Metab. 2020 Oct;2(10):1034-1045. doi: 10.1038/s42255-020-0261-2. Epub 2020 Aug 24. Nat Metab. 2020. PMID: 32839596 Free PMC article.
322 results