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Nr4A1 modulates inflammation-associated intestinal fibrosis and dampens fibrogenic signaling in myofibroblasts.
Pulakazhi Venu VK, Alston L, Iftinca M, Tsai YC, Stephens M, Warriyar K V V, Rehal S, Hudson G, Szczepanski H, von der Weid PY, Altier C, Hirota SA. Pulakazhi Venu VK, et al. Among authors: hirota sa. Am J Physiol Gastrointest Liver Physiol. 2021 Sep 1;321(3):G280-G297. doi: 10.1152/ajpgi.00338.2019. Epub 2021 Jul 21. Am J Physiol Gastrointest Liver Physiol. 2021. PMID: 34288735 Free article.
The P2Y6 receptor mediates Clostridium difficile toxin-induced CXCL8/IL-8 production and intestinal epithelial barrier dysfunction.
Hansen A, Alston L, Tulk SE, Schenck LP, Grassie ME, Alhassan BF, Veermalla AT, Al-Bashir S, Gendron FP, Altier C, MacDonald JA, Beck PL, Hirota SA. Hansen A, et al. Among authors: hirota sa. PLoS One. 2013 Nov 22;8(11):e81491. doi: 10.1371/journal.pone.0081491. eCollection 2013. PLoS One. 2013. PMID: 24278446 Free PMC article.
Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation.
Garg A, Zhao A, Erickson SL, Mukherjee S, Lau AJ, Alston L, Chang TK, Mani S, Hirota SA. Garg A, et al. Among authors: hirota sa. J Pharmacol Exp Ther. 2016 Oct;359(1):91-101. doi: 10.1124/jpet.116.234096. Epub 2016 Jul 20. J Pharmacol Exp Ther. 2016. PMID: 27440420 Free PMC article.
Constitutive androstane receptor regulates the intestinal mucosal response to injury.
Hudson GM, Flannigan KL, Erickson SL, Vicentini FA, Zamponi A, Hirota CL, Alston L, Altier C, Ghosh S, Rioux KP, Mani S, Chang TK, Hirota SA. Hudson GM, et al. Among authors: hirota cl, hirota sa. Br J Pharmacol. 2017 Jun;174(12):1857-1871. doi: 10.1111/bph.13787. Epub 2017 Apr 19. Br J Pharmacol. 2017. PMID: 28320072 Free PMC article.
A simple, cost-effective method for generating murine colonic 3D enteroids and 2D monolayers for studies of primary epithelial cell function.
Fernando EH, Dicay M, Stahl M, Gordon MH, Vegso A, Baggio C, Alston L, Lopes F, Baker K, Hirota S, McKay DM, Vallance B, MacNaughton WK. Fernando EH, et al. Am J Physiol Gastrointest Liver Physiol. 2017 Nov 1;313(5):G467-G475. doi: 10.1152/ajpgi.00152.2017. Epub 2017 Jul 27. Am J Physiol Gastrointest Liver Physiol. 2017. PMID: 28751424 Free article.
Heat shock protein-27 and sex-selective regulation of muscarinic and proteinase-activated receptor 2-mediated vasodilatation: differential sensitivity to endothelial NOS inhibition.
Pulakazhi Venu VK, Saifeddine M, Mihara K, El-Daly M, Belke D, Dean JLE, O'Brien ER, Hirota SA, Hollenberg MD. Pulakazhi Venu VK, et al. Among authors: hirota sa. Br J Pharmacol. 2018 Jun;175(11):2063-2076. doi: 10.1111/bph.14200. Epub 2018 Apr 25. Br J Pharmacol. 2018. PMID: 29532457 Free PMC article.
Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress.
El-Daly M, Pulakazhi Venu VK, Saifeddine M, Mihara K, Kang S, Fedak PWM, Alston LA, Hirota SA, Ding H, Triggle CR, Hollenberg MD. El-Daly M, et al. Among authors: hirota sa. Vascul Pharmacol. 2018 Oct;109:56-71. doi: 10.1016/j.vph.2018.06.006. Epub 2018 Jun 13. Vascul Pharmacol. 2018. PMID: 29908295
An intact microbiota is required for the gastrointestinal toxicity of the immunosuppressant mycophenolate mofetil.
Flannigan KL, Taylor MR, Pereira SK, Rodriguez-Arguello J, Moffat AW, Alston L, Wang X, Poon KK, Beck PL, Rioux KP, Jonnalagadda M, Chelikani PK, Galipeau HJ, Lewis IA, Workentine ML, Greenway SC, Hirota SA. Flannigan KL, et al. Among authors: hirota sa. J Heart Lung Transplant. 2018 Sep;37(9):1047-1059. doi: 10.1016/j.healun.2018.05.002. Epub 2018 May 23. J Heart Lung Transplant. 2018. PMID: 30173823
Effects of Azithromycin on Behavior, Pathologic Signs, and Changes in Cytokines, Chemokines, and Neutrophil Migration in C57BL/6 Mice Exposed to Dextran Sulfate Sodium.
Anderson SJ, Lockhart JS, Estaki M, Quin C, Hirota SA, Alston L, Buret AG, Hancock TM, Petri B, Gibson DL, Morck DW. Anderson SJ, et al. Among authors: hirota sa. Comp Med. 2019 Feb 1;69(1):4-15. doi: 10.30802/AALAS-CM-18-000001. Epub 2018 Dec 13. Comp Med. 2019. PMID: 30545428 Free PMC article.
61 results