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GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis.
Kremer DM, Nelson BS, Lin L, Yarosz EL, Halbrook CJ, Kerk SA, Sajjakulnukit P, Myers A, Thurston G, Hou SW, Carpenter ES, Andren AC, Nwosu ZC, Cusmano N, Wisner S, Mbah NE, Shan M, Das NK, Magnuson B, Little AC, Savani MR, Ramos J, Gao T, Sastra SA, Palermo CF, Badgley MA, Zhang L, Asara JM, McBrayer SK, di Magliano MP, Crawford HC, Shah YM, Olive KP, Lyssiotis CA. Kremer DM, et al. Among authors: little ac. Nat Commun. 2021 Aug 11;12(1):4860. doi: 10.1038/s41467-021-24859-2. Nat Commun. 2021. PMID: 34381026 Free PMC article.
Direct cysteine sulfenylation drives activation of the Src kinase.
Heppner DE, Dustin CM, Liao C, Hristova M, Veith C, Little AC, Ahlers BA, White SL, Deng B, Lam YW, Li J, van der Vliet A. Heppner DE, et al. Among authors: little ac. Nat Commun. 2018 Oct 30;9(1):4522. doi: 10.1038/s41467-018-06790-1. Nat Commun. 2018. PMID: 30375386 Free PMC article.
Development of an Enhanced-Throughput Radial Cell Migration Device.
Oliver CR, Little AC, Westerhof TM, Pathanjeli P, Yates JA, Merajver SD. Oliver CR, et al. Among authors: little ac. SLAS Technol. 2021 Apr;26(2):200-208. doi: 10.1177/2472630320971217. Epub 2020 Nov 12. SLAS Technol. 2021. PMID: 33183152 Free PMC article.
Acrolein and thiol-reactive electrophiles suppress allergen-induced innate airway epithelial responses by inhibition of DUOX1 and EGFR.
Danyal K, de Jong W, O'Brien E, Bauer RA, Heppner DE, Little AC, Hristova M, Habibovic A, van der Vliet A. Danyal K, et al. Among authors: little ac. Am J Physiol Lung Cell Mol Physiol. 2016 Nov 1;311(5):L913-L923. doi: 10.1152/ajplung.00276.2016. Epub 2016 Sep 9. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27612966 Free PMC article.
Paradoxical roles of dual oxidases in cancer biology.
Little AC, Sulovari A, Danyal K, Heppner DE, Seward DJ, van der Vliet A. Little AC, et al. Free Radic Biol Med. 2017 Sep;110:117-132. doi: 10.1016/j.freeradbiomed.2017.05.024. Epub 2017 May 31. Free Radic Biol Med. 2017. PMID: 28578013 Free PMC article. Review.
149 results