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Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors.
Abramson A, Frederiksen MR, Vegge A, Jensen B, Poulsen M, Mouridsen B, Jespersen MO, Kirk RK, Windum J, Hubálek F, Water JJ, Fels J, Gunnarsson SB, Bohr A, Straarup EM, Ley MWH, Lu X, Wainer J, Collins J, Tamang S, Ishida K, Hayward A, Herskind P, Buckley ST, Roxhed N, Langer R, Rahbek U, Traverso G. Abramson A, et al. Among authors: buckley st. Nat Biotechnol. 2022 Jan;40(1):103-109. doi: 10.1038/s41587-021-01024-0. Epub 2021 Aug 30. Nat Biotechnol. 2022. PMID: 34462588 Free PMC article.
An ingestible self-orienting system for oral delivery of macromolecules.
Abramson A, Caffarel-Salvador E, Khang M, Dellal D, Silverstein D, Gao Y, Frederiksen MR, Vegge A, Hubálek F, Water JJ, Friderichsen AV, Fels J, Kirk RK, Cleveland C, Collins J, Tamang S, Hayward A, Landh T, Buckley ST, Roxhed N, Rahbek U, Langer R, Traverso G. Abramson A, et al. Among authors: buckley st. Science. 2019 Feb 8;363(6427):611-615. doi: 10.1126/science.aau2277. Science. 2019. PMID: 30733413 Free PMC article.
Implantable system for chronotherapy.
Lee SH, Wan Q, Wentworth A, Ballinger I, Ishida K, Collins JE, Tamang S, Huang HW, Li C, Hess K, Lopes A, Kirtane AR, Lee JS, Lee S, Chen W, Wong K, Selsing G, Kim H, Buckley ST, Hayward A, Langer R, Traverso G. Lee SH, et al. Among authors: buckley st. Sci Adv. 2021 Nov 26;7(48):eabj4624. doi: 10.1126/sciadv.abj4624. Epub 2021 Nov 26. Sci Adv. 2021. PMID: 34826238 Free PMC article.
Transcellular stomach absorption of a derivatized glucagon-like peptide-1 receptor agonist.
Buckley ST, Bækdal TA, Vegge A, Maarbjerg SJ, Pyke C, Ahnfelt-Rønne J, Madsen KG, Schéele SG, Alanentalo T, Kirk RK, Pedersen BL, Skyggebjerg RB, Benie AJ, Strauss HM, Wahlund PO, Bjerregaard S, Farkas E, Fekete C, Søndergaard FL, Borregaard J, Hartoft-Nielsen ML, Knudsen LB. Buckley ST, et al. Sci Transl Med. 2018 Nov 14;10(467):eaar7047. doi: 10.1126/scitranslmed.aar7047. Sci Transl Med. 2018. PMID: 30429357 Clinical Trial.
Combining mass spectrometry and machine learning to discover bioactive peptides.
Madsen CT, Refsgaard JC, Teufel FG, Kjærulff SK, Wang Z, Meng G, Jessen C, Heljo P, Jiang Q, Zhao X, Wu B, Zhou X, Tang Y, Jeppesen JF, Kelstrup CD, Buckley ST, Tullin S, Nygaard-Jensen J, Chen X, Zhang F, Olsen JV, Han D, Grønborg M, de Lichtenberg U. Madsen CT, et al. Among authors: buckley st. Nat Commun. 2022 Oct 20;13(1):6235. doi: 10.1038/s41467-022-34031-z. Nat Commun. 2022. PMID: 36266275 Free PMC article.
Semaglutide lowers body weight in rodents via distributed neural pathways.
Gabery S, Salinas CG, Paulsen SJ, Ahnfelt-Rønne J, Alanentalo T, Baquero AF, Buckley ST, Farkas E, Fekete C, Frederiksen KS, Helms HCC, Jeppesen JF, John LM, Pyke C, Nøhr J, Lu TT, Polex-Wolf J, Prevot V, Raun K, Simonsen L, Sun G, Szilvásy-Szabó A, Willenbrock H, Secher A, Knudsen LB, Hogendorf WFJ. Gabery S, et al. Among authors: buckley st. JCI Insight. 2020 Mar 26;5(6):e133429. doi: 10.1172/jci.insight.133429. JCI Insight. 2020. PMID: 32213703 Free PMC article.
44 results