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Oral delivery of systemic monoclonal antibodies, peptides and small molecules using gastric auto-injectors.
Abramson A, Frederiksen MR, Vegge A, Jensen B, Poulsen M, Mouridsen B, Jespersen MO, Kirk RK, Windum J, Hubálek F, Water JJ, Fels J, Gunnarsson SB, Bohr A, Straarup EM, Ley MWH, Lu X, Wainer J, Collins J, Tamang S, Ishida K, Hayward A, Herskind P, Buckley ST, Roxhed N, Langer R, Rahbek U, Traverso G. Abramson A, et al. Among authors: straarup em. Nat Biotechnol. 2022 Jan;40(1):103-109. doi: 10.1038/s41587-021-01024-0. Epub 2021 Aug 30. Nat Biotechnol. 2022. PMID: 34462588 Free PMC article.
FGF21 decreases food intake and body weight in obese Göttingen minipigs.
Christoffersen B, Straarup EM, Lykkegaard K, Fels JJ, Sass-Ørum K, Zhang X, Raun K, Andersen B. Christoffersen B, et al. Among authors: straarup em. Diabetes Obes Metab. 2019 Mar;21(3):592-600. doi: 10.1111/dom.13560. Epub 2018 Nov 20. Diabetes Obes Metab. 2019. PMID: 30328263
FGF21 decreases body weight without reducing food intake or bone mineral density in high-fat fed obese rhesus macaque monkeys.
Andersen B, Straarup EM, Heppner KM, Takahashi DL, Raffaele V, Dissen GA, Lewandowski K, Bödvarsdottir TB, Raun K, Grove KL, Kievit P. Andersen B, et al. Among authors: straarup em. Int J Obes (Lond). 2018 Jun;42(6):1151-1160. doi: 10.1038/s41366-018-0080-7. Epub 2018 Jun 11. Int J Obes (Lond). 2018. PMID: 29892039 Free PMC article.
Lipid Embolism in Obese Göttingen Minipigs.
Viuff BM, Straarup EM, Nowak J, Morgills L, Skydsgaard M, Sjögren I, Wulff BS, Christoffersen BØ. Viuff BM, et al. Among authors: straarup em. Toxicol Pathol. 2020 Feb;48(2):379-392. doi: 10.1177/0192623319880464. Epub 2019 Oct 23. Toxicol Pathol. 2020. PMID: 31645215
LNA-mediated microRNA silencing in non-human primates.
Elmén J, Lindow M, Schütz S, Lawrence M, Petri A, Obad S, Lindholm M, Hedtjärn M, Hansen HF, Berger U, Gullans S, Kearney P, Sarnow P, Straarup EM, Kauppinen S. Elmén J, et al. Among authors: straarup em. Nature. 2008 Apr 17;452(7189):896-9. doi: 10.1038/nature06783. Epub 2008 Mar 26. Nature. 2008. PMID: 18368051
Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver.
Elmén J, Lindow M, Silahtaroglu A, Bak M, Christensen M, Lind-Thomsen A, Hedtjärn M, Hansen JB, Hansen HF, Straarup EM, McCullagh K, Kearney P, Kauppinen S. Elmén J, et al. Among authors: straarup em. Nucleic Acids Res. 2008 Mar;36(4):1153-62. doi: 10.1093/nar/gkm1113. Epub 2007 Dec 23. Nucleic Acids Res. 2008. PMID: 18158304 Free PMC article.
Silencing of microRNA families by seed-targeting tiny LNAs.
Obad S, dos Santos CO, Petri A, Heidenblad M, Broom O, Ruse C, Fu C, Lindow M, Stenvang J, Straarup EM, Hansen HF, Koch T, Pappin D, Hannon GJ, Kauppinen S. Obad S, et al. Among authors: straarup em. Nat Genet. 2011 Mar 20;43(4):371-8. doi: 10.1038/ng.786. Nat Genet. 2011. PMID: 21423181 Free PMC article.
36 results