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Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.
Nat Struct Mol Biol. 2022 Aug;29(8):767-773. doi: 10.1038/s41594-022-00804-9. Epub 2022 Jul 21.
Nat Struct Mol Biol. 2022.
PMID: 35864164
Free PMC article.
Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors.
Curnock AP, Bossi G, Kumaran J, Bawden LJ, Figueiredo R, Tawar R, Wiseman K, Henderson E, Hoong SJ, Gonzalez V, Ghadbane H, Knight DE, O'Dwyer R, Overton DX, Lucato CM, Smith NM, Reis CR, Page K, Whaley LM, McCully ML, Hearty S, Mahon TM, Weber P.
Curnock AP, et al. Among authors: lucato cm.
JCI Insight. 2021 Oct 22;6(20):e152468. doi: 10.1172/jci.insight.152468.
JCI Insight. 2021.
PMID: 34491911
Free PMC article.
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Structural analysis of the PTEN:P-Rex2 signaling complex reveals how cancer-associated mutations coordinate to hyperactivate Rac1.
D'Andrea L, Lucato CM, Marquez EA, Chang YG, Civciristov S, Mastos C, Lupton CJ, Huang C, Elmlund H, Schittenhelm RB, Mitchell CA, Whisstock JC, Halls ML, Ellisdon AM.
D'Andrea L, et al. Among authors: lucato cm.
Sci Signal. 2021 May 4;14(681):eabc4078. doi: 10.1126/scisignal.abc4078.
Sci Signal. 2021.
PMID: 33947796
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P-Rex1 and P-Rex2 RacGEFs and cancer.
Srijakotre N, Man J, Ooms LM, Lucato CM, Ellisdon AM, Mitchell CA.
Srijakotre N, et al. Among authors: lucato cm.
Biochem Soc Trans. 2017 Aug 15;45(4):963-77. doi: 10.1042/BST20160269. Epub 2017 Jul 14.
Biochem Soc Trans. 2017.
PMID: 28710285
Review.
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Amyloidogenicity at a Distance: How Distal Protein Regions Modulate Aggregation in Disease.
Lucato CM, Lupton CJ, Halls ML, Ellisdon AM.
Lucato CM, et al.
J Mol Biol. 2017 May 5;429(9):1289-1304. doi: 10.1016/j.jmb.2017.03.021. Epub 2017 Mar 22.
J Mol Biol. 2017.
PMID: 28342736
Review.
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The Phosphatidylinositol (3,4,5)-Trisphosphate-dependent Rac Exchanger 1·Ras-related C3 Botulinum Toxin Substrate 1 (P-Rex1·Rac1) Complex Reveals the Basis of Rac1 Activation in Breast Cancer Cells.
Lucato CM, Halls ML, Ooms LM, Liu HJ, Mitchell CA, Whisstock JC, Ellisdon AM.
Lucato CM, et al.
J Biol Chem. 2015 Aug 21;290(34):20827-20840. doi: 10.1074/jbc.M115.660456. Epub 2015 Jun 24.
J Biol Chem. 2015.
PMID: 26112412
Free PMC article.
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