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Structure of the metastatic factor P-Rex1 reveals a two-layered autoinhibitory mechanism.
Chang YG, Lupton CJ, Bayly-Jones C, Keen AC, D'Andrea L, Lucato CM, Steele JR, Venugopal H, Schittenhelm RB, Whisstock JC, Halls ML, Ellisdon AM. Chang YG, et al. Among authors: lucato cm. Nat Struct Mol Biol. 2022 Aug;29(8):767-773. doi: 10.1038/s41594-022-00804-9. Epub 2022 Jul 21. Nat Struct Mol Biol. 2022. PMID: 35864164 Free PMC article.
Cell-targeted PD-1 agonists that mimic PD-L1 are potent T cell inhibitors.
Curnock AP, Bossi G, Kumaran J, Bawden LJ, Figueiredo R, Tawar R, Wiseman K, Henderson E, Hoong SJ, Gonzalez V, Ghadbane H, Knight DE, O'Dwyer R, Overton DX, Lucato CM, Smith NM, Reis CR, Page K, Whaley LM, McCully ML, Hearty S, Mahon TM, Weber P. Curnock AP, et al. Among authors: lucato cm. JCI Insight. 2021 Oct 22;6(20):e152468. doi: 10.1172/jci.insight.152468. JCI Insight. 2021. PMID: 34491911 Free PMC article.
P-Rex1 and P-Rex2 RacGEFs and cancer.
Srijakotre N, Man J, Ooms LM, Lucato CM, Ellisdon AM, Mitchell CA. Srijakotre N, et al. Among authors: lucato cm. Biochem Soc Trans. 2017 Aug 15;45(4):963-77. doi: 10.1042/BST20160269. Epub 2017 Jul 14. Biochem Soc Trans. 2017. PMID: 28710285 Review.