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Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy.
Drake JC, Wilson RJ, Laker RC, Guan Y, Spaulding HR, Nichenko AS, Shen W, Shang H, Dorn MV, Huang K, Zhang M, Bandara AB, Brisendine MH, Kashatus JA, Sharma PR, Young A, Gautam J, Cao R, Wallrabe H, Chang PA, Wong M, Desjardins EM, Hawley SA, Christ GJ, Kashatus DF, Miller CL, Wolf MJ, Periasamy A, Steinberg GR, Hardie DG, Yan Z. Drake JC, et al. Among authors: desjardins em. Proc Natl Acad Sci U S A. 2021 Sep 14;118(37):e2025932118. doi: 10.1073/pnas.2025932118. Proc Natl Acad Sci U S A. 2021. PMID: 34493662 Free PMC article.
Lack of Adipocyte AMPK Exacerbates Insulin Resistance and Hepatic Steatosis through Brown and Beige Adipose Tissue Function.
Mottillo EP, Desjardins EM, Crane JD, Smith BK, Green AE, Ducommun S, Henriksen TI, Rebalka IA, Razi A, Sakamoto K, Scheele C, Kemp BE, Hawke TJ, Ortega J, Granneman JG, Steinberg GR. Mottillo EP, et al. Among authors: desjardins em. Cell Metab. 2016 Jul 12;24(1):118-29. doi: 10.1016/j.cmet.2016.06.006. Cell Metab. 2016. PMID: 27411013 Free PMC article.
Salsalate (Salicylate) Uncouples Mitochondria, Improves Glucose Homeostasis, and Reduces Liver Lipids Independent of AMPK-β1.
Smith BK, Ford RJ, Desjardins EM, Green AE, Hughes MC, Houde VP, Day EA, Marcinko K, Crane JD, Mottillo EP, Perry CG, Kemp BE, Tarnopolsky MA, Steinberg GR. Smith BK, et al. Among authors: desjardins em. Diabetes. 2016 Nov;65(11):3352-3361. doi: 10.2337/db16-0564. Epub 2016 Aug 23. Diabetes. 2016. PMID: 27554471 Free PMC article.
Treatment of nonalcoholic fatty liver disease: role of AMPK.
Smith BK, Marcinko K, Desjardins EM, Lally JS, Ford RJ, Steinberg GR. Smith BK, et al. Among authors: desjardins em. Am J Physiol Endocrinol Metab. 2016 Oct 1;311(4):E730-E740. doi: 10.1152/ajpendo.00225.2016. Epub 2016 Aug 30. Am J Physiol Endocrinol Metab. 2016. PMID: 27577854 Free article. Review.
FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis.
Mottillo EP, Desjardins EM, Fritzen AM, Zou VZ, Crane JD, Yabut JM, Kiens B, Erion DM, Lanba A, Granneman JG, Talukdar S, Steinberg GR. Mottillo EP, et al. Among authors: desjardins em. Mol Metab. 2017 Apr 5;6(6):471-481. doi: 10.1016/j.molmet.2017.04.001. eCollection 2017 Jun. Mol Metab. 2017. PMID: 28580278 Free PMC article.
Ablating the protein TBC1D1 impairs contraction-induced sarcolemmal glucose transporter 4 redistribution but not insulin-mediated responses in rats.
Whitfield J, Paglialunga S, Smith BK, Miotto PM, Simnett G, Robson HL, Jain SS, Herbst EAF, Desjardins EM, Dyck DJ, Spriet LL, Steinberg GR, Holloway GP. Whitfield J, et al. Among authors: desjardins em. J Biol Chem. 2017 Oct 6;292(40):16653-16664. doi: 10.1074/jbc.M117.806786. Epub 2017 Aug 14. J Biol Chem. 2017. PMID: 28808062 Free PMC article.
32 results