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A microenvironment-inspired synthetic three-dimensional model for pancreatic ductal adenocarcinoma organoids.
Below CR, Kelly J, Brown A, Humphries JD, Hutton C, Xu J, Lee BY, Cintas C, Zhang X, Hernandez-Gordillo V, Stockdale L, Goldsworthy MA, Geraghty J, Foster L, O'Reilly DA, Schedding B, Askari J, Burns J, Hodson N, Smith DL, Lally C, Ashton G, Knight D, Mironov A, Banyard A, Eble JA, Morton JP, Humphries MJ, Griffith LG, Jørgensen C. Below CR, et al. Among authors: cintas c. Nat Mater. 2022 Jan;21(1):110-119. doi: 10.1038/s41563-021-01085-1. Epub 2021 Sep 13. Nat Mater. 2022. PMID: 34518665 Free PMC article.
Acinar-to-Ductal Metaplasia Induced by Transforming Growth Factor Beta Facilitates KRASG12D-driven Pancreatic Tumorigenesis.
Chuvin N, Vincent DF, Pommier RM, Alcaraz LB, Gout J, Caligaris C, Yacoub K, Cardot V, Roger E, Kaniewski B, Martel S, Cintas C, Goddard-Léon S, Colombe A, Valantin J, Gadot N, Servoz E, Morton J, Goddard I, Couvelard A, Rebours V, Guillermet J, Sansom OJ, Treilleux I, Valcourt U, Sentis S, Dubus P, Bartholin L. Chuvin N, et al. Among authors: cintas c. Cell Mol Gastroenterol Hepatol. 2017 May 31;4(2):263-282. doi: 10.1016/j.jcmgh.2017.05.005. eCollection 2017 Sep. Cell Mol Gastroenterol Hepatol. 2017. PMID: 28752115 Free PMC article.
Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component.
Thibault B, Ramos-Delgado F, Pons-Tostivint E, Therville N, Cintas C, Arcucci S, Cassant-Sourdy S, Reyes-Castellanos G, Tosolini M, Villard AV, Cayron C, Baer R, Bertrand-Michel J, Pagan D, Ferreira Da Mota D, Yan H, Falcomatà C, Muscari F, Bournet B, Delord JP, Aksoy E, Carrier A, Cordelier P, Saur D, Basset C, Guillermet-Guibert J. Thibault B, et al. Among authors: cintas c. EMBO Mol Med. 2021 Jul 7;13(7):e13502. doi: 10.15252/emmm.202013502. Epub 2021 May 25. EMBO Mol Med. 2021. PMID: 34033220 Free PMC article.
Pancreatic cell plasticity and cancer initiation induced by oncogenic Kras is completely dependent on wild-type PI 3-kinase p110α.
Baer R, Cintas C, Dufresne M, Cassant-Sourdy S, Schönhuber N, Planque L, Lulka H, Couderc B, Bousquet C, Garmy-Susini B, Vanhaesebroeck B, Pyronnet S, Saur D, Guillermet-Guibert J. Baer R, et al. Among authors: cintas c. Genes Dev. 2014 Dec 1;28(23):2621-35. doi: 10.1101/gad.249409.114. Genes Dev. 2014. PMID: 25452273 Free PMC article.
Phosphoproteomics Identifies PI3K Inhibitor-selective Adaptive Responses in Pancreatic Cancer Cell Therapy and Resistance.
Cintas C, Douche T, Dantes Z, Mouton-Barbosa E, Bousquet MP, Cayron C, Therville N, Pont F, Ramos-Delgado F, Guyon C, Garmy-Susini B, Cappello P, Burlet-Schiltz O, Hirsch E, Gomez-Brouchet A, Thibault B, Reichert M, Guillermet-Guibert J. Cintas C, et al. Mol Cancer Ther. 2021 Dec;20(12):2433-2445. doi: 10.1158/1535-7163.MCT-20-0981. Epub 2021 Sep 22. Mol Cancer Ther. 2021. PMID: 34552006
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