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Bispecific antibodies targeting distinct regions of the spike protein potently neutralize SARS-CoV-2 variants of concern.
Cho H, Gonzales-Wartz KK, Huang D, Yuan M, Peterson M, Liang J, Beutler N, Torres JL, Cong Y, Postnikova E, Bangaru S, Talana CA, Shi W, Yang ES, Zhang Y, Leung K, Wang L, Peng L, Skinner J, Li S, Wu NC, Liu H, Dacon C, Moyer T, Cohen M, Zhao M, Lee FE, Weinberg RS, Douagi I, Gross R, Schmaljohn C, Pegu A, Mascola JR, Holbrook M, Nemazee D, Rogers TF, Ward AB, Wilson IA, Crompton PD, Tan J. Cho H, et al. Among authors: crompton pd. Sci Transl Med. 2021 Oct 20;13(616):eabj5413. doi: 10.1126/scitranslmed.abj5413. Epub 2021 Oct 20. Sci Transl Med. 2021. PMID: 34519517 Free PMC article.
HIV Malaria Co-Infection Is Associated with Atypical Memory B Cell Expansion and a Reduced Antibody Response to a Broad Array of Plasmodium falciparum Antigens in Rwandan Adults.
Subramaniam KS, Skinner J, Ivan E, Mutimura E, Kim RS, Feintuch CM, Portugal S, Anastos K, Crompton PD, Daily JP. Subramaniam KS, et al. Among authors: crompton pd. PLoS One. 2015 Apr 30;10(4):e0124412. doi: 10.1371/journal.pone.0124412. eCollection 2015. PLoS One. 2015. PMID: 25928218 Free PMC article.
Circulating Th1-Cell-type Tfh Cells that Exhibit Impaired B Cell Help Are Preferentially Activated during Acute Malaria in Children.
Obeng-Adjei N, Portugal S, Tran TM, Yazew TB, Skinner J, Li S, Jain A, Felgner PL, Doumbo OK, Kayentao K, Ongoiba A, Traore B, Crompton PD. Obeng-Adjei N, et al. Among authors: crompton pd. Cell Rep. 2015 Oct 13;13(2):425-39. doi: 10.1016/j.celrep.2015.09.004. Epub 2015 Oct 1. Cell Rep. 2015. PMID: 26440897 Free PMC article.
Malaria-induced interferon-γ drives the expansion of Tbethi atypical memory B cells.
Obeng-Adjei N, Portugal S, Holla P, Li S, Sohn H, Ambegaonkar A, Skinner J, Bowyer G, Doumbo OK, Traore B, Pierce SK, Crompton PD. Obeng-Adjei N, et al. Among authors: crompton pd. PLoS Pathog. 2017 Sep 27;13(9):e1006576. doi: 10.1371/journal.ppat.1006576. eCollection 2017 Sep. PLoS Pathog. 2017. PMID: 28953967 Free PMC article.
PD-1 Expression on NK Cells in Malaria-Exposed Individuals Is Associated with Diminished Natural Cytotoxicity and Enhanced Antibody-Dependent Cellular Cytotoxicity.
Moebius J, Guha R, Peterson M, Abdi K, Skinner J, Li S, Arora G, Traore B, Rajagopalan S, Long EO, Crompton PD. Moebius J, et al. Among authors: crompton pd. Infect Immun. 2020 Feb 20;88(3):e00711-19. doi: 10.1128/IAI.00711-19. Print 2020 Feb 20. Infect Immun. 2020. PMID: 31907195 Free PMC article.
Plasmodium falciparum-specific IgM B cells dominate in children, expand with malaria, and produce functional IgM.
Hopp CS, Sekar P, Diouf A, Miura K, Boswell K, Skinner J, Tipton CM, Peterson ME, Chambers MJ, Andrews S, Lu J, Tan J, Li S, Doumbo S, Kayentao K, Ongoiba A, Traore B, Portugal S, Sun PD, Long C, Koup RA, Long EO, McDermott AB, Crompton PD. Hopp CS, et al. Among authors: crompton pd. J Exp Med. 2021 Apr 5;218(4):e20200901. doi: 10.1084/jem.20200901. J Exp Med. 2021. PMID: 33661303 Free PMC article.
Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants.
Cho H, Gonzales-Wartz KK, Huang D, Yuan M, Peterson M, Liang J, Beutler N, Torres JL, Cong Y, Postnikova E, Bangaru S, Talana CA, Shi W, Yang ES, Zhang Y, Leung K, Wang L, Peng L, Skinner J, Li S, Wu NC, Liu H, Dacon C, Moyer T, Cohen M, Zhao M, Lee FE, Weinberg RS, Douagi I, Gross R, Schmaljohn C, Pegu A, Mascola JR, Holbrook M, Nemazee D, Rogers TF, Ward AB, Wilson IA, Crompton PD, Tan J. Cho H, et al. Among authors: crompton pd. bioRxiv [Preprint]. 2021 Apr 1:2021.04.01.437942. doi: 10.1101/2021.04.01.437942. bioRxiv. 2021. PMID: 33821267 Free PMC article. Updated. Preprint.
104 results