Sigal A - Search Results

1

T cell derived HIV-1 is present in the CSF in the face of suppressive antiretroviral therapy.

Lustig G, Cele S, Karim F, Derache A, Ngoepe A, Khan K, Gosnell BI, Moosa MS, Ntshuba N, Marais S, Jeena PM, Govender K, Adamson J, Kløverpris H, Gupta RK, Harrichandparsad R, Patel VB, Sigal A. Lustig G, et al. Among authors: sigal a. PLoS Pathog. 2021 Sep 23;17(9):e1009871. doi: 10.1371/journal.ppat.1009871. eCollection 2021 Sep. PLoS Pathog. 2021. PMID: 34555123 Free PMC article.

2

Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy.

Sigal A, Kim JT, Balazs AB, Dekel E, Mayo A, Milo R, Baltimore D. Sigal A, et al. Nature. 2011 Aug 17;477(7362):95-8. doi: 10.1038/nature10347. Nature. 2011. PMID: 21849975

3

Short communication: Lower baseline CD4 count is associated with a greater propensity toward virological failure in a cohort of South African HIV patients.

Costiniuk CT, Sigal A, Jenabian MA, Nijs P, Wilson D. Costiniuk CT, et al. Among authors: sigal a. AIDS Res Hum Retroviruses. 2014 Jun;30(6):531-4. doi: 10.1089/aid.2014.0011. AIDS Res Hum Retroviruses. 2014. PMID: 24803320

4

HIV Cell-to-Cell Spread Results in Earlier Onset of Viral Gene Expression by Multiple Infections per Cell.

Boullé M, Müller TG, Dähling S, Ganga Y, Jackson L, Mahamed D, Oom L, Lustig G, Neher RA, Sigal A. Boullé M, et al. Among authors: sigal a. PLoS Pathog. 2016 Nov 3;12(11):e1005964. doi: 10.1371/journal.ppat.1005964. eCollection 2016 Nov. PLoS Pathog. 2016. PMID: 27812216 Free PMC article.

5

Intracellular growth of Mycobacterium tuberculosis after macrophage cell death leads to serial killing of host cells.

Mahamed D, Boulle M, Ganga Y, Mc Arthur C, Skroch S, Oom L, Catinas O, Pillay K, Naicker M, Rampersad S, Mathonsi C, Hunter J, Wong EB, Suleman M, Sreejit G, Pym AS, Lustig G, Sigal A. Mahamed D, et al. Among authors: sigal a. Elife. 2017 Jan 28;6:e22028. doi: 10.7554/eLife.22028. Elife. 2017. PMID: 28130921 Free PMC article.

6

Dendritic cells efficiently transmit HIV to T Cells in a tenofovir and raltegravir insensitive manner.

Kim JT, Chang E, Sigal A, Baltimore D. Kim JT, et al. Among authors: sigal a. PLoS One. 2018 Jan 2;13(1):e0189945. doi: 10.1371/journal.pone.0189945. eCollection 2018. PLoS One. 2018. PMID: 29293546 Free PMC article.

7

Incomplete inhibition of HIV infection results in more HIV infected lymph node cells by reducing cell death.

Jackson L, Hunter J, Cele S, Ferreira IM, Young AC, Karim F, Madansein R, Dullabh KJ, Chen CY, Buckels NJ, Ganga Y, Khan K, Boulle M, Lustig G, Neher RA, Sigal A. Jackson L, et al. Among authors: sigal a. Elife. 2018 Mar 20;7:e30134. doi: 10.7554/eLife.30134. Elife. 2018. PMID: 29555018 Free PMC article.

8

Interference with HIV infection of the first cell is essential for viral clearance at sub-optimal levels of drug inhibition.

Moyano A, Lustig G, Rodel HE, Antal T, Sigal A. Moyano A, et al. Among authors: sigal a. PLoS Comput Biol. 2020 Feb 4;16(2):e1007482. doi: 10.1371/journal.pcbi.1007482. eCollection 2020 Feb. PLoS Comput Biol. 2020. PMID: 32017770 Free PMC article.

9

Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant.

Madhi SA, Baillie V, Cutland CL, Voysey M, Koen AL, Fairlie L, Padayachee SD, Dheda K, Barnabas SL, Bhorat QE, Briner C, Kwatra G, Ahmed K, Aley P, Bhikha S, Bhiman JN, Bhorat AE, du Plessis J, Esmail A, Groenewald M, Horne E, Hwa SH, Jose A, Lambe T, Laubscher M, Malahleha M, Masenya M, Masilela M, McKenzie S, Molapo K, Moultrie A, Oelofse S, Patel F, Pillay S, Rhead S, Rodel H, Rossouw L, Taoushanis C, Tegally H, Thombrayil A, van Eck S, Wibmer CK, Durham NM, Kelly EJ, Villafana TL, Gilbert S, Pollard AJ, de Oliveira T, Moore PL, Sigal A, Izu A; NGS-SA Group; Wits-VIDA COVID Group. Madhi SA, et al. Among authors: sigal a. N Engl J Med. 2021 May 20;384(20):1885-1898. doi: 10.1056/NEJMoa2102214. Epub 2021 Mar 16. N Engl J Med. 2021. PMID: 33725432 Free PMC article. Clinical Trial.

10

Escape of SARS-CoV-2 501Y.V2 from neutralization by convalescent plasma.

Cele S, Gazy I, Jackson L, Hwa SH, Tegally H, Lustig G, Giandhari J, Pillay S, Wilkinson E, Naidoo Y, Karim F, Ganga Y, Khan K, Bernstein M, Balazs AB, Gosnell BI, Hanekom W, Moosa MS; Network for Genomic Surveillance in South Africa; COMMIT-KZN Team; Lessells RJ, de Oliveira T, Sigal A. Cele S, et al. Among authors: sigal a. Nature. 2021 May;593(7857):142-146. doi: 10.1038/s41586-021-03471-w. Epub 2021 Mar 29. Nature. 2021. PMID: 33780970 Free PMC article.

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