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Obesity and hyperinsulinemia drive adipocytes to activate a cell cycle program and senesce.
Li Q, Hagberg CE, Silva Cascales H, Lang S, Hyvönen MT, Salehzadeh F, Chen P, Alexandersson I, Terezaki E, Harms MJ, Kutschke M, Arifen N, Krämer N, Aouadi M, Knibbe C, Boucher J, Thorell A, Spalding KL. Li Q, et al. Among authors: thorell a. Nat Med. 2021 Nov;27(11):1941-1953. doi: 10.1038/s41591-021-01501-8. Epub 2021 Oct 4. Nat Med. 2021. PMID: 34608330
Impact of fat mass and distribution on lipid turnover in human adipose tissue.
Spalding KL, Bernard S, Näslund E, Salehpour M, Possnert G, Appelsved L, Fu KY, Alkass K, Druid H, Thorell A, Rydén M, Arner P. Spalding KL, et al. Among authors: thorell a. Nat Commun. 2017 May 23;8:15253. doi: 10.1038/ncomms15253. Nat Commun. 2017. PMID: 28534500 Free PMC article.
Adipose lipid turnover and long-term changes in body weight.
Arner P, Bernard S, Appelsved L, Fu KY, Andersson DP, Salehpour M, Thorell A, Rydén M, Spalding KL. Arner P, et al. Among authors: thorell a. Nat Med. 2019 Sep;25(9):1385-1389. doi: 10.1038/s41591-019-0565-5. Epub 2019 Sep 9. Nat Med. 2019. PMID: 31501613
Liver macrophages inhibit the endogenous antioxidant response in obesity-associated insulin resistance.
Azzimato V, Jager J, Chen P, Morgantini C, Levi L, Barreby E, Sulen A, Oses C, Willerbrords J, Xu C, Li X, Shen JX, Akbar N, Haag L, Ellis E, Wålhen K, Näslund E, Thorell A, Choudhury RP, Lauschke VM, Rydén M, Craige SM, Aouadi M. Azzimato V, et al. Among authors: thorell a. Sci Transl Med. 2020 Feb 26;12(532):eaaw9709. doi: 10.1126/scitranslmed.aaw9709. Sci Transl Med. 2020. PMID: 32102936
Hepatic miR-144 Drives Fumarase Activity Preventing NRF2 Activation During Obesity.
Azzimato V, Chen P, Barreby E, Morgantini C, Levi L, Vankova A, Jager J, Sulen A, Diotallevi M, Shen JX, Miller A, Ellis E, Rydén M, Näslund E, Thorell A, Lauschke VM, Channon KM, Crabtree MJ, Haschemi A, Craige SM, Mori M, Spallotta F, Aouadi M. Azzimato V, et al. Among authors: thorell a. Gastroenterology. 2021 Dec;161(6):1982-1997.e11. doi: 10.1053/j.gastro.2021.08.030. Epub 2021 Aug 21. Gastroenterology. 2021. PMID: 34425095 Free article.
Regional impact of adipose tissue morphology on the metabolic profile in morbid obesity.
Hoffstedt J, Arner E, Wahrenberg H, Andersson DP, Qvisth V, Löfgren P, Rydén M, Thörne A, Wirén M, Palmér M, Thorell A, Toft E, Arner P. Hoffstedt J, et al. Among authors: thorell a. Diabetologia. 2010 Dec;53(12):2496-503. doi: 10.1007/s00125-010-1889-3. Epub 2010 Sep 10. Diabetologia. 2010. PMID: 20830466 Clinical Trial.
234 results