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Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis.
Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Słabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL. Kim PG, et al. Among authors: charles jf. J Exp Med. 2021 Dec 6;218(12):e20211872. doi: 10.1084/jem.20211872. Epub 2021 Oct 26. J Exp Med. 2021. PMID: 34698806 Free PMC article.
CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts.
Greenblatt MB, Park KH, Oh H, Kim JM, Shin DY, Lee JM, Lee JW, Singh A, Lee KY, Hu D, Xiao C, Charles JF, Penninger JM, Lotinun S, Baron R, Ghosh S, Shim JH. Greenblatt MB, et al. Among authors: charles jf. J Exp Med. 2015 Jul 27;212(8):1283-301. doi: 10.1084/jem.20150407. Epub 2015 Jul 20. J Exp Med. 2015. PMID: 26195726 Free PMC article.
Osteoclasts: more than 'bone eaters'.
Charles JF, Aliprantis AO. Charles JF, et al. Trends Mol Med. 2014 Aug;20(8):449-59. doi: 10.1016/j.molmed.2014.06.001. Epub 2014 Jul 6. Trends Mol Med. 2014. PMID: 25008556 Free PMC article. Review.
Obesity-Linked PPARγ S273 Phosphorylation Promotes Insulin Resistance through Growth Differentiation Factor 3.
Hall JA, Ramachandran D, Roh HC, DiSpirito JR, Belchior T, Zushin PH, Palmer C, Hong S, Mina AI, Liu B, Deng Z, Aryal P, Jacobs C, Tenen D, Brown CW, Charles JF, Shulman GI, Kahn BB, Tsai LTY, Rosen ED, Spiegelman BM, Banks AS. Hall JA, et al. Among authors: charles jf. Cell Metab. 2020 Oct 6;32(4):665-675.e6. doi: 10.1016/j.cmet.2020.08.016. Epub 2020 Sep 16. Cell Metab. 2020. PMID: 32941798 Free PMC article.
IL-1β-driven osteoclastogenic Tregs accelerate bone erosion in arthritis.
Levescot A, Chang MH, Schnell J, Nelson-Maney N, Yan J, Martínez-Bonet M, Grieshaber-Bouyer R, Lee PY, Wei K, Blaustein RB, Morris A, Wactor A, Iwakura Y, Lederer JA, Rao DA, Charles JF, Nigrovic PA. Levescot A, et al. Among authors: charles jf. J Clin Invest. 2021 Sep 15;131(18):e141008. doi: 10.1172/JCI141008. J Clin Invest. 2021. PMID: 34343136 Free PMC article.
165 results