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Glomerular endothelial cell senescence drives age-related kidney disease through PAI-1.
Cohen C, Le Goff O, Soysouvanh F, Vasseur F, Tanou M, Nguyen C, Amrouche L, Le Guen J, Saltel-Fulero O, Meunier T, Nguyen-Khoa T, Rabant M, Nochy D, Legendre C, Friedlander G, Childs BG, Baker DJ, Knebelmann B, Anglicheau D, Milliat F, Terzi F. Cohen C, et al. Among authors: childs bg. EMBO Mol Med. 2021 Nov 8;13(11):e14146. doi: 10.15252/emmm.202114146. Epub 2021 Nov 2. EMBO Mol Med. 2021. PMID: 34725920 Free PMC article.
Senescence and apoptosis: dueling or complementary cell fates?
Childs BG, Baker DJ, Kirkland JL, Campisi J, van Deursen JM. Childs BG, et al. EMBO Rep. 2014 Nov;15(11):1139-53. doi: 10.15252/embr.201439245. Epub 2014 Oct 13. EMBO Rep. 2014. PMID: 25312810 Free PMC article. Review.
Progressive Cellular Senescence Mediates Renal Dysfunction in Ischemic Nephropathy.
Kim SR, Puranik AS, Jiang K, Chen X, Zhu XY, Taylor I, Khodadadi-Jamayran A, Lerman A, Hickson LJ, Childs BG, Textor SC, Tchkonia T, Niewold TB, Kirkland JL, Lerman LO. Kim SR, et al. Among authors: childs bg. J Am Soc Nephrol. 2021 Aug;32(8):1987-2004. doi: 10.1681/ASN.2020091373. Epub 2021 Jun 16. J Am Soc Nephrol. 2021. PMID: 34135081 Free PMC article.
Naturally occurring p16(Ink4a)-positive cells shorten healthy lifespan.
Baker DJ, Childs BG, Durik M, Wijers ME, Sieben CJ, Zhong J, Saltness RA, Jeganathan KB, Verzosa GC, Pezeshki A, Khazaie K, Miller JD, van Deursen JM. Baker DJ, et al. Among authors: childs bg. Nature. 2016 Feb 11;530(7589):184-9. doi: 10.1038/nature16932. Epub 2016 Feb 3. Nature. 2016. PMID: 26840489 Free PMC article.
B cell senescence takes guts.
Childs BG, Graves SI, Baker DJ. Childs BG, et al. Nat Cell Biol. 2023 Jun;25(6):800-801. doi: 10.1038/s41556-023-01153-5. Nat Cell Biol. 2023. PMID: 37225966 Free PMC article.
17 results