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An oral SARS-CoV-2 Mpro inhibitor clinical candidate for the treatment of COVID-19.
Owen DR, Allerton CMN, Anderson AS, Aschenbrenner L, Avery M, Berritt S, Boras B, Cardin RD, Carlo A, Coffman KJ, Dantonio A, Di L, Eng H, Ferre R, Gajiwala KS, Gibson SA, Greasley SE, Hurst BL, Kadar EP, Kalgutkar AS, Lee JC, Lee J, Liu W, Mason SW, Noell S, Novak JJ, Obach RS, Ogilvie K, Patel NC, Pettersson M, Rai DK, Reese MR, Sammons MF, Sathish JG, Singh RSP, Steppan CM, Stewart AE, Tuttle JB, Updyke L, Verhoest PR, Wei L, Yang Q, Zhu Y. Owen DR, et al. Among authors: berritt s. Science. 2021 Dec 24;374(6575):1586-1593. doi: 10.1126/science.abl4784. Epub 2021 Nov 2. Science. 2021. PMID: 34726479 Free article.
Probing the chemical 'reactome' with high-throughput experimentation data.
King-Smith E, Berritt S, Bernier L, Hou X, Klug-McLeod JL, Mustakis J, Sach NW, Tucker JW, Yang Q, Howard RM, Lee AA. King-Smith E, et al. Among authors: berritt s. Nat Chem. 2024 Apr;16(4):633-643. doi: 10.1038/s41557-023-01393-w. Epub 2024 Jan 2. Nat Chem. 2024. PMID: 38168924 Free PMC article.
Organic chemistry. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules.
Buitrago Santanilla A, Regalado EL, Pereira T, Shevlin M, Bateman K, Campeau LC, Schneeweis J, Berritt S, Shi ZC, Nantermet P, Liu Y, Helmy R, Welch CJ, Vachal P, Davies IW, Cernak T, Dreher SD. Buitrago Santanilla A, et al. Among authors: berritt s. Science. 2015 Jan 2;347(6217):49-53. doi: 10.1126/science.1259203. Epub 2014 Nov 20. Science. 2015. PMID: 25554781
Synthetic studies of heterocyclic natural products.
Joullié MM, Berritt S, Forbeck EM. Joullié MM, et al. Among authors: berritt s. Curr Opin Drug Discov Devel. 2008 Nov;11(6):829-52. Curr Opin Drug Discov Devel. 2008. PMID: 18946847 Review.
Structure-activity relationships of ustiloxin analogues.
Joullié MM, Berritt S, Hamel E. Joullié MM, et al. Among authors: berritt s. Tetrahedron Lett. 2011 Apr;52(17):2136-2139. doi: 10.1016/j.tetlet.2010.11.165. Tetrahedron Lett. 2011. PMID: 21607116 Free PMC article.
Structural plasticity of tubulin assembly probed by vinca-domain ligands.
Ranaivoson FM, Gigant B, Berritt S, Joullié M, Knossow M. Ranaivoson FM, et al. Among authors: berritt s. Acta Crystallogr D Biol Crystallogr. 2012 Aug;68(Pt 8):927-34. doi: 10.1107/S0907444912017143. Epub 2012 Jul 7. Acta Crystallogr D Biol Crystallogr. 2012. PMID: 22868758
33 results