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Oral prodrug of remdesivir parent GS-441524 is efficacious against SARS-CoV-2 in ferrets.
Cox RM, Wolf JD, Lieber CM, Sourimant J, Lin MJ, Babusis D, DuPont V, Chan J, Barrett KT, Lye D, Kalla R, Chun K, Mackman RL, Ye C, Cihlar T, Martinez-Sobrido L, Greninger AL, Bilello JP, Plemper RK. Cox RM, et al. Among authors: lin mj. Nat Commun. 2021 Nov 5;12(1):6415. doi: 10.1038/s41467-021-26760-4. Nat Commun. 2021. PMID: 34741049 Free PMC article.
Orally efficacious broad-spectrum allosteric inhibitor of paramyxovirus polymerase.
Cox RM, Sourimant J, Toots M, Yoon JJ, Ikegame S, Govindarajan M, Watkinson RE, Thibault P, Makhsous N, Lin MJ, Marengo JR, Sticher Z, Kolykhalov AA, Natchus MG, Greninger AL, Lee B, Plemper RK. Cox RM, et al. Among authors: lin mj. Nat Microbiol. 2020 Oct;5(10):1232-1246. doi: 10.1038/s41564-020-0752-7. Epub 2020 Jul 13. Nat Microbiol. 2020. PMID: 32661315 Free PMC article.
A Bifluorescent-Based Assay for the Identification of Neutralizing Antibodies against SARS-CoV-2 Variants of Concern In Vitro and In Vivo.
Chiem K, Morales Vasquez D, Silvas JA, Park JG, Piepenbrink MS, Sourimant J, Lin MJ, Greninger AL, Plemper RK, Torrelles JB, Walter MR, de la Torre JC, Kobie JK, Ye C, Martinez-Sobrido L. Chiem K, et al. Among authors: lin mj. J Virol. 2021 Oct 27;95(22):e0112621. doi: 10.1128/JVI.01126-21. Epub 2021 Sep 8. J Virol. 2021. PMID: 34495697 Free PMC article.
Analysis of SARS-CoV-2 infection dynamic in vivo using reporter-expressing viruses.
Ye C, Chiem K, Park JG, Silvas JA, Morales Vasquez D, Sourimant J, Lin MJ, Greninger AL, Plemper RK, Torrelles JB, Kobie JJ, Walter MR, de la Torre JC, Martinez-Sobrido L. Ye C, et al. Among authors: lin mj. Proc Natl Acad Sci U S A. 2021 Oct 12;118(41):e2111593118. doi: 10.1073/pnas.2111593118. Proc Natl Acad Sci U S A. 2021. PMID: 34561300 Free PMC article.
De novo emergence of a remdesivir resistance mutation during treatment of persistent SARS-CoV-2 infection in an immunocompromised patient: a case report.
Gandhi S, Klein J, Robertson AJ, Peña-Hernández MA, Lin MJ, Roychoudhury P, Lu P, Fournier J, Ferguson D, Mohamed Bakhash SAK, Catherine Muenker M, Srivathsan A, Wunder EA Jr, Kerantzas N, Wang W, Lindenbach B, Pyle A, Wilen CB, Ogbuagu O, Greninger AL, Iwasaki A, Schulz WL, Ko AI. Gandhi S, et al. Among authors: lin mj. Nat Commun. 2022 Mar 17;13(1):1547. doi: 10.1038/s41467-022-29104-y. Nat Commun. 2022. PMID: 35301314 Free PMC article.
A SARS-CoV-2 Nucleocapsid Variant that Affects Antigen Test Performance.
Bourassa L, Perchetti GA, Phung Q, Lin MJ, Mills MG, Roychoudhury P, Harmon KG, Reed JC, Greninger AL. Bourassa L, et al. Among authors: lin mj. J Clin Virol. 2021 Aug;141:104900. doi: 10.1016/j.jcv.2021.104900. Epub 2021 Jun 17. J Clin Virol. 2021. PMID: 34171548 Free PMC article.
Inhibition of Coronavirus Entry In Vitro and Ex Vivo by a Lipid-Conjugated Peptide Derived from the SARS-CoV-2 Spike Glycoprotein HRC Domain.
Outlaw VK, Bovier FT, Mears MC, Cajimat MN, Zhu Y, Lin MJ, Addetia A, Lieberman NAP, Peddu V, Xie X, Shi PY, Greninger AL, Gellman SH, Bente DA, Moscona A, Porotto M. Outlaw VK, et al. Among authors: lin mj. mBio. 2020 Oct 20;11(5):e01935-20. doi: 10.1128/mBio.01935-20. mBio. 2020. PMID: 33082259 Free PMC article.
520 results