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A tissue-bioengineering strategy for modeling rare human kidney diseases in vivo.
Hernandez JOR, Wang X, Vazquez-Segoviano M, Lopez-Marfil M, Sobral-Reyes MF, Moran-Horowich A, Sundberg M, Lopez-Cantu DO, Probst CK, Ruiz-Esparza GU, Giannikou K, Abdi R, Henske EP, Kwiatkowski DJ, Sahin M, Lemos DR. Hernandez JOR, et al. Among authors: probst ck. Nat Commun. 2021 Nov 11;12(1):6496. doi: 10.1038/s41467-021-26596-y. Nat Commun. 2021. PMID: 34764250 Free PMC article.
Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex.
Kovalenko A, Sanin A, Kosmas K, Zhang L, Wang J, Akl EW, Giannikou K, Probst CK, Hougard TR, Rue RW, Krymskaya VP, Asara JM, Lam HC, Kwiatkowski DJ, Henske EP, Filippakis H. Kovalenko A, et al. Among authors: probst ck. Cancer Res. 2021 Apr 15;81(8):2086-2100. doi: 10.1158/0008-5472.CAN-20-2218. Epub 2021 Feb 16. Cancer Res. 2021. PMID: 33593821 Free PMC article.
Screening for YAP Inhibitors Identifies Statins as Modulators of Fibrosis.
Santos DM, Pantano L, Pronzati G, Grasberger P, Probst CK, Black KE, Spinney JJ, Hariri LP, Nichols R, Lin Y, Bieler M, Seither P, Nicklin P, Wyatt D, Tager AM, Medoff BD. Santos DM, et al. Among authors: probst ck. Am J Respir Cell Mol Biol. 2020 Apr;62(4):479-492. doi: 10.1165/rcmb.2019-0296OC. Am J Respir Cell Mol Biol. 2020. PMID: 31944822 Free PMC article.
ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis.
Lagares D, Ghassemi-Kakroodi P, Tremblay C, Santos A, Probst CK, Franklin A, Santos DM, Grasberger P, Ahluwalia N, Montesi SB, Shea BS, Black KE, Knipe R, Blati M, Baron M, Wu B, Fahmi H, Gandhi R, Pardo A, Selman M, Wu J, Pelletier JP, Martel-Pelletier J, Tager AM, Kapoor M. Lagares D, et al. Among authors: probst ck. Nat Med. 2017 Dec;23(12):1405-1415. doi: 10.1038/nm.4419. Epub 2017 Oct 23. Nat Med. 2017. PMID: 29058717 Free PMC article.
Mechanosignaling through YAP and TAZ drives fibroblast activation and fibrosis.
Liu F, Lagares D, Choi KM, Stopfer L, Marinković A, Vrbanac V, Probst CK, Hiemer SE, Sisson TH, Horowitz JC, Rosas IO, Fredenburgh LE, Feghali-Bostwick C, Varelas X, Tager AM, Tschumperlin DJ. Liu F, et al. Among authors: probst ck. Am J Physiol Lung Cell Mol Physiol. 2015 Feb 15;308(4):L344-57. doi: 10.1152/ajplung.00300.2014. Epub 2014 Dec 12. Am J Physiol Lung Cell Mol Physiol. 2015. PMID: 25502501 Free PMC article. Clinical Trial.
Autotaxin activity increases locally following lung injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis.
Black KE, Berdyshev E, Bain G, Castelino FV, Shea BS, Probst CK, Fontaine BA, Bronova I, Goulet L, Lagares D, Ahluwalia N, Knipe RS, Natarajan V, Tager AM. Black KE, et al. Among authors: probst ck. FASEB J. 2016 Jun;30(6):2435-50. doi: 10.1096/fj.201500197R. Epub 2016 Mar 22. FASEB J. 2016. PMID: 27006447 Free PMC article.
Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization.
Funke M, Knudsen L, Lagares D, Ebener S, Probst CK, Fontaine BA, Franklin A, Kellner M, Kühnel M, Matthieu S, Grothausmann R, Chun J, Roberts JD Jr, Ochs M, Tager AM. Funke M, et al. Among authors: probst ck. Am J Respir Cell Mol Biol. 2016 Jul;55(1):105-16. doi: 10.1165/rcmb.2015-0152OC. Am J Respir Cell Mol Biol. 2016. PMID: 27082727 Free PMC article.
23 results