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Spatial mapping of protein composition and tissue organization: a primer for multiplexed antibody-based imaging.
Hickey JW, Neumann EK, Radtke AJ, Camarillo JM, Beuschel RT, Albanese A, McDonough E, Hatler J, Wiblin AE, Fisher J, Croteau J, Small EC, Sood A, Caprioli RM, Angelo RM, Nolan GP, Chung K, Hewitt SM, Germain RN, Spraggins JM, Lundberg E, Snyder MP, Kelleher NL, Saka SK. Hickey JW, et al. Among authors: kelleher nl. Nat Methods. 2022 Mar;19(3):284-295. doi: 10.1038/s41592-021-01316-y. Epub 2021 Nov 22. Nat Methods. 2022. PMID: 34811556 Free PMC article. Review.
Mapping intact protein isoforms in discovery mode using top-down proteomics.
Tran JC, Zamdborg L, Ahlf DR, Lee JE, Catherman AD, Durbin KR, Tipton JD, Vellaichamy A, Kellie JF, Li M, Wu C, Sweet SM, Early BP, Siuti N, LeDuc RD, Compton PD, Thomas PM, Kelleher NL. Tran JC, et al. Among authors: kelleher nl. Nature. 2011 Oct 30;480(7376):254-8. doi: 10.1038/nature10575. Nature. 2011. PMID: 22037311 Free PMC article.
Systems Proteomics View of the Endogenous Human Claudin Protein Family.
Liu F, Koval M, Ranganathan S, Fanayan S, Hancock WS, Lundberg EK, Beavis RC, Lane L, Duek P, McQuade L, Kelleher NL, Baker MS. Liu F, et al. Among authors: kelleher nl. J Proteome Res. 2016 Feb 5;15(2):339-59. doi: 10.1021/acs.jproteome.5b00769. Epub 2016 Jan 12. J Proteome Res. 2016. PMID: 26680015 Free PMC article. Review.
An informatic framework for decoding protein complexes by top-down mass spectrometry.
Skinner OS, Havugimana PC, Haverland NA, Fornelli L, Early BP, Greer JB, Fellers RT, Durbin KR, Do Vale LH, Melani RD, Seckler HS, Nelp MT, Belov ME, Horning SR, Makarov AA, LeDuc RD, Bandarian V, Compton PD, Kelleher NL. Skinner OS, et al. Among authors: kelleher nl. Nat Methods. 2016 Mar;13(3):237-40. doi: 10.1038/nmeth.3731. Epub 2016 Jan 18. Nat Methods. 2016. PMID: 26780093 Free PMC article.
How many human proteoforms are there?
Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B. Aebersold R, et al. Among authors: kelleher nl. Nat Chem Biol. 2018 Feb 14;14(3):206-214. doi: 10.1038/nchembio.2576. Nat Chem Biol. 2018. PMID: 29443976 Free PMC article.
Multiplexed mass spectrometry of individual ions improves measurement of proteoforms and their complexes.
Kafader JO, Melani RD, Durbin KR, Ikwuagwu B, Early BP, Fellers RT, Beu SC, Zabrouskov V, Makarov AA, Maze JT, Shinholt DL, Yip PF, Tullman-Ercek D, Senko MW, Compton PD, Kelleher NL. Kafader JO, et al. Among authors: kelleher nl. Nat Methods. 2020 Apr;17(4):391-394. doi: 10.1038/s41592-020-0764-5. Epub 2020 Mar 2. Nat Methods. 2020. PMID: 32123391 Free PMC article.
Targeted detection and quantitation of histone modifications from 1,000 cells.
Abshiru NA, Sikora JW, Camarillo JM, Morris JA, Compton PD, Lee T, Neelamraju Y, Haddox S, Sheridan C, Carroll M, Cripe LD, Tallman MS, Paietta EM, Melnick AM, Thomas PM, Garrett-Bakelman FE, Kelleher NL. Abshiru NA, et al. Among authors: kelleher nl. PLoS One. 2020 Oct 26;15(10):e0240829. doi: 10.1371/journal.pone.0240829. eCollection 2020. PLoS One. 2020. PMID: 33104722 Free PMC article.
428 results