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Xist nucleates local protein gradients to propagate silencing across the X chromosome.
Markaki Y, Gan Chong J, Wang Y, Jacobson EC, Luong C, Tan SYX, Jachowicz JW, Strehle M, Maestrini D, Banerjee AK, Mistry BA, Dror I, Dossin F, Schöneberg J, Heard E, Guttman M, Chou T, Plath K. Markaki Y, et al. Among authors: heard e. Cell. 2021 Dec 9;184(25):6174-6192.e32. doi: 10.1016/j.cell.2021.10.022. Epub 2021 Nov 4. Cell. 2021. PMID: 34813726 Free PMC article.
Jarid2 Is Implicated in the Initial Xist-Induced Targeting of PRC2 to the Inactive X Chromosome.
da Rocha ST, Boeva V, Escamilla-Del-Arenal M, Ancelin K, Granier C, Matias NR, Sanulli S, Chow J, Schulz E, Picard C, Kaneko S, Helin K, Reinberg D, Stewart AF, Wutz A, Margueron R, Heard E. da Rocha ST, et al. Among authors: heard e. Mol Cell. 2014 Jan 23;53(2):301-16. doi: 10.1016/j.molcel.2014.01.002. Mol Cell. 2014. PMID: 24462204 Free article.
Systematic discovery of Xist RNA binding proteins.
Chu C, Zhang QC, da Rocha ST, Flynn RA, Bharadwaj M, Calabrese JM, Magnuson T, Heard E, Chang HY. Chu C, et al. Among authors: heard e. Cell. 2015 Apr 9;161(2):404-16. doi: 10.1016/j.cell.2015.03.025. Epub 2015 Apr 2. Cell. 2015. PMID: 25843628 Free PMC article.
The Implication of Early Chromatin Changes in X Chromosome Inactivation.
Żylicz JJ, Bousard A, Žumer K, Dossin F, Mohammad E, da Rocha ST, Schwalb B, Syx L, Dingli F, Loew D, Cramer P, Heard E. Żylicz JJ, et al. Among authors: heard e. Cell. 2019 Jan 10;176(1-2):182-197.e23. doi: 10.1016/j.cell.2018.11.041. Epub 2018 Dec 27. Cell. 2019. PMID: 30595450 Free PMC article.
The bipartite TAD organization of the X-inactivation center ensures opposing developmental regulation of Tsix and Xist.
van Bemmel JG, Galupa R, Gard C, Servant N, Picard C, Davies J, Szempruch AJ, Zhan Y, Żylicz JJ, Nora EP, Lameiras S, de Wit E, Gentien D, Baulande S, Giorgetti L, Guttman M, Hughes JR, Higgs DR, Gribnau J, Heard E. van Bemmel JG, et al. Among authors: heard e. Nat Genet. 2019 Jun;51(6):1024-1034. doi: 10.1038/s41588-019-0412-0. Epub 2019 May 27. Nat Genet. 2019. PMID: 31133748 Free PMC article.
Xist RNA in action: Past, present, and future.
Loda A, Heard E. Loda A, et al. Among authors: heard e. PLoS Genet. 2019 Sep 19;15(9):e1008333. doi: 10.1371/journal.pgen.1008333. eCollection 2019 Sep. PLoS Genet. 2019. PMID: 31537017 Free PMC article. Review.
SPEN integrates transcriptional and epigenetic control of X-inactivation.
Dossin F, Pinheiro I, Żylicz JJ, Roensch J, Collombet S, Le Saux A, Chelmicki T, Attia M, Kapoor V, Zhan Y, Dingli F, Loew D, Mercher T, Dekker J, Heard E. Dossin F, et al. Among authors: heard e. Nature. 2020 Feb;578(7795):455-460. doi: 10.1038/s41586-020-1974-9. Epub 2020 Feb 5. Nature. 2020. PMID: 32025035 Free PMC article.
The Molecular and Nuclear Dynamics of X-Chromosome Inactivation.
Dossin F, Heard E. Dossin F, et al. Among authors: heard e. Cold Spring Harb Perspect Biol. 2022 May 17;14(4):a040196. doi: 10.1101/cshperspect.a040196. Cold Spring Harb Perspect Biol. 2022. PMID: 34312245 Free PMC article. Review.
SPEN is required for Xist upregulation during initiation of X chromosome inactivation.
Robert-Finestra T, Tan BF, Mira-Bontenbal H, Timmers E, Gontan C, Merzouk S, Giaimo BD, Dossin F, van IJcken WFJ, Martens JWM, Borggrefe T, Heard E, Gribnau J. Robert-Finestra T, et al. Among authors: heard e. Nat Commun. 2021 Dec 1;12(1):7000. doi: 10.1038/s41467-021-27294-5. Nat Commun. 2021. PMID: 34853312 Free PMC article.
Xist nucleates local protein gradients to propagate silencing across the X chromosome.
Markaki Y, Chong JG, Wang Y, Jacobson EC, Luong C, Tan SYX, Jachowicz JW, Strehle M, Maestrini D, Banerjee AK, Mistry BA, Dror I, Dossin F, Schӧneberg J, Heard E, Guttman M, Chou T, Plath K. Markaki Y, et al. Among authors: heard e. Cell. 2021 Dec 9;184(25):6212. doi: 10.1016/j.cell.2021.11.028. Cell. 2021. PMID: 34890555 Free PMC article. No abstract available.
219 results