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Xist nucleates local protein gradients to propagate silencing across the X chromosome.
Markaki Y, Gan Chong J, Wang Y, Jacobson EC, Luong C, Tan SYX, Jachowicz JW, Strehle M, Maestrini D, Banerjee AK, Mistry BA, Dror I, Dossin F, Schöneberg J, Heard E, Guttman M, Chou T, Plath K. Markaki Y, et al. Among authors: plath k. Cell. 2021 Dec 9;184(25):6174-6192.e32. doi: 10.1016/j.cell.2021.10.022. Epub 2021 Nov 4. Cell. 2021. PMID: 34813726 Free PMC article.
Xist RNA and the mechanism of X chromosome inactivation.
Plath K, Mlynarczyk-Evans S, Nusinow DA, Panning B. Plath K, et al. Annu Rev Genet. 2002;36:233-78. doi: 10.1146/annurev.genet.36.042902.092433. Epub 2002 Jun 11. Annu Rev Genet. 2002. PMID: 12429693 Review.
Female human iPSCs retain an inactive X chromosome.
Tchieu J, Kuoy E, Chin MH, Trinh H, Patterson M, Sherman SP, Aimiuwu O, Lindgren A, Hakimian S, Zack JA, Clark AT, Pyle AD, Lowry WE, Plath K. Tchieu J, et al. Among authors: plath k. Cell Stem Cell. 2010 Sep 3;7(3):329-42. doi: 10.1016/j.stem.2010.06.024. Epub 2010 Aug 19. Cell Stem Cell. 2010. PMID: 20727844 Free PMC article.
X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency.
Pasque V, Tchieu J, Karnik R, Uyeda M, Sadhu Dimashkie A, Case D, Papp B, Bonora G, Patel S, Ho R, Schmidt R, McKee R, Sado T, Tada T, Meissner A, Plath K. Pasque V, et al. Among authors: plath k. Cell. 2014 Dec 18;159(7):1681-97. doi: 10.1016/j.cell.2014.11.040. Cell. 2014. PMID: 25525883 Free PMC article.
The Xist lncRNA interacts directly with SHARP to silence transcription through HDAC3.
McHugh CA, Chen CK, Chow A, Surka CF, Tran C, McDonel P, Pandya-Jones A, Blanco M, Burghard C, Moradian A, Sweredoski MJ, Shishkin AA, Su J, Lander ES, Hess S, Plath K, Guttman M. McHugh CA, et al. Among authors: plath k. Nature. 2015 May 14;521(7551):232-6. doi: 10.1038/nature14443. Epub 2015 Apr 27. Nature. 2015. PMID: 25915022 Free PMC article.
154 results