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Developing antisense oligonucleotides for a TECPR2 mutation-induced, ultra-rare neurological disorder using patient-derived cellular models.
Williams LA, Gerber DJ, Elder A, Tseng WC, Baru V, Delaney-Busch N, Ambrosi C, Mahimkar G, Joshi V, Shah H, Harikrishnan K, Upadhyay H, Rajendran SH, Dhandapani A, Meier J, Ryan SJ, Lewarch C, Black L, Douville J, Cinquino S, Legakis H, Nalbach K, Behrends C, Sato A, Galluzzi L, Yu TW, Brown D, Agrawal S, Margulies D, Kopin A, Dempsey GT. Williams LA, et al. Among authors: gerber dj. Mol Ther Nucleic Acids. 2022 Jun 22;29:189-203. doi: 10.1016/j.omtn.2022.06.015. eCollection 2022 Sep 13. Mol Ther Nucleic Acids. 2022. PMID: 35860385 Free PMC article.
Targeting neuronal function for CNS drug discovery.
Hempel CM, Werley CA, Dempsey GT, Gerber DJ. Hempel CM, et al. Among authors: gerber dj. Drug Discov Today Technol. 2017 Mar;23:17-25. doi: 10.1016/j.ddtec.2017.03.005. Epub 2017 May 6. Drug Discov Today Technol. 2017. PMID: 28647082 Review.
A system for performing high throughput assays of synaptic function.
Hempel CM, Sivula M, Levenson JM, Rose DM, Li B, Sirianni AC, Xia E, Ryan TA, Gerber DJ, Cottrell JR. Hempel CM, et al. Among authors: gerber dj. PLoS One. 2011;6(10):e25999. doi: 10.1371/journal.pone.0025999. Epub 2011 Oct 5. PLoS One. 2011. PMID: 21998743 Free PMC article.
Working memory impairment in calcineurin knock-out mice is associated with alterations in synaptic vesicle cycling and disruption of high-frequency synaptic and network activity in prefrontal cortex.
Cottrell JR, Levenson JM, Kim SH, Gibson HE, Richardson KA, Sivula M, Li B, Ashford CJ, Heindl KA, Babcock RJ, Rose DM, Hempel CM, Wiig KA, Laeng P, Levin ME, Ryan TA, Gerber DJ. Cottrell JR, et al. Among authors: gerber dj. J Neurosci. 2013 Jul 3;33(27):10938-49. doi: 10.1523/JNEUROSCI.5362-12.2013. J Neurosci. 2013. PMID: 23825400 Free PMC article.
Direct excitation of parvalbumin-positive interneurons by M1 muscarinic acetylcholine receptors: roles in cellular excitability, inhibitory transmission and cognition.
Yi F, Ball J, Stoll KE, Satpute VC, Mitchell SM, Pauli JL, Holloway BB, Johnston AD, Nathanson NM, Deisseroth K, Gerber DJ, Tonegawa S, Lawrence JJ. Yi F, et al. Among authors: gerber dj. J Physiol. 2014 Aug 15;592(16):3463-94. doi: 10.1113/jphysiol.2014.275453. Epub 2014 May 30. J Physiol. 2014. PMID: 24879872 Free PMC article.
30 results