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Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer.
Raghavan S, Winter PS, Navia AW, Williams HL, DenAdel A, Lowder KE, Galvez-Reyes J, Kalekar RL, Mulugeta N, Kapner KS, Raghavan MS, Borah AA, Liu N, Väyrynen SA, Costa AD, Ng RWS, Wang J, Hill EK, Ragon DY, Brais LK, Jaeger AM, Spurr LF, Li YY, Cherniack AD, Booker MA, Cohen EF, Tolstorukov MY, Wakiro I, Rotem A, Johnson BE, McFarland JM, Sicinska ET, Jacks TE, Sullivan RJ, Shapiro GI, Clancy TE, Perez K, Rubinson DA, Ng K, Cleary JM, Crawford L, Manalis SR, Nowak JA, Wolpin BM, Hahn WC, Aguirre AJ, Shalek AK. Raghavan S, et al. Among authors: manalis sr. Cell. 2021 Dec 9;184(25):6119-6137.e26. doi: 10.1016/j.cell.2021.11.017. Cell. 2021. PMID: 34890551 Free PMC article.
Characterizing deformability and surface friction of cancer cells.
Byun S, Son S, Amodei D, Cermak N, Shaw J, Kang JH, Hecht VC, Winslow MM, Jacks T, Mallick P, Manalis SR. Byun S, et al. Among authors: manalis sr. Proc Natl Acad Sci U S A. 2013 May 7;110(19):7580-5. doi: 10.1073/pnas.1218806110. Epub 2013 Apr 22. Proc Natl Acad Sci U S A. 2013. PMID: 23610435 Free PMC article.
Linking single-cell measurements of mass, growth rate, and gene expression.
Kimmerling RJ, Prakadan SM, Gupta AJ, Calistri NL, Stevens MM, Olcum S, Cermak N, Drake RS, Pelton K, De Smet F, Ligon KL, Shalek AK, Manalis SR. Kimmerling RJ, et al. Among authors: manalis sr. Genome Biol. 2018 Nov 27;19(1):207. doi: 10.1186/s13059-018-1576-0. Genome Biol. 2018. PMID: 30482222 Free PMC article.
Optofluidic real-time cell sorter for longitudinal CTC studies in mouse models of cancer.
Hamza B, Ng SR, Prakadan SM, Delgado FF, Chin CR, King EM, Yang LF, Davidson SM, DeGouveia KL, Cermak N, Navia AW, Winter PS, Drake RS, Tammela T, Li CM, Papagiannakopoulos T, Gupta AJ, Shaw Bagnall J, Knudsen SM, Vander Heiden MG, Wasserman SC, Jacks T, Shalek AK, Manalis SR. Hamza B, et al. Among authors: manalis sr. Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2232-2236. doi: 10.1073/pnas.1814102116. Epub 2019 Jan 23. Proc Natl Acad Sci U S A. 2019. PMID: 30674677 Free PMC article.
Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice.
Hamza B, Miller AB, Meier L, Stockslager M, Ng SR, King EM, Lin L, DeGouveia KL, Mulugeta N, Calistri NL, Strouf H, Bray C, Rodriguez F, Freed-Pastor WA, Chin CR, Jaramillo GC, Burger ML, Weinberg RA, Shalek AK, Jacks T, Manalis SR. Hamza B, et al. Among authors: manalis sr. Nat Commun. 2021 Sep 28;12(1):5680. doi: 10.1038/s41467-021-25917-5. Nat Commun. 2021. PMID: 34584084 Free PMC article.
Pyruvate kinase isoform expression alters nucleotide synthesis to impact cell proliferation.
Lunt SY, Muralidhar V, Hosios AM, Israelsen WJ, Gui DY, Newhouse L, Ogrodzinski M, Hecht V, Xu K, Acevedo PN, Hollern DP, Bellinger G, Dayton TL, Christen S, Elia I, Dinh AT, Stephanopoulos G, Manalis SR, Yaffe MB, Andrechek ER, Fendt SM, Vander Heiden MG. Lunt SY, et al. Among authors: manalis sr. Mol Cell. 2015 Jan 8;57(1):95-107. doi: 10.1016/j.molcel.2014.10.027. Epub 2014 Dec 4. Mol Cell. 2015. PMID: 25482511 Free PMC article.
Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate.
Stevens MM, Maire CL, Chou N, Murakami MA, Knoff DS, Kikuchi Y, Kimmerling RJ, Liu H, Haidar S, Calistri NL, Cermak N, Olcum S, Cordero NA, Idbaih A, Wen PY, Weinstock DM, Ligon KL, Manalis SR. Stevens MM, et al. Among authors: manalis sr. Nat Biotechnol. 2016 Nov;34(11):1161-1167. doi: 10.1038/nbt.3697. Epub 2016 Oct 10. Nat Biotechnol. 2016. PMID: 27723727 Free PMC article.
89 results