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IMI European Lead Factory - democratizing access to high-throughput screening.
Jones PS, Boucharens S, McElroy SP, Morrison A, Honarnejad S, van Boeckel S, van den Hurk H, Basting D, Hüser J, Jaroch S, Ottow E, Benningshof J, Folmer RHA, Leemhuis F, Kramer-Verhulst PM, Nies VJM, Orrling KM, Rijnders T, Pfander C, Engkvist O, Pairaudeau G, Simpson PB, Ortholand JY, Roche D, Dömling A, Kühnert SM, Roevens PWM, van Vlijmen H, van Wanrooij EJA, Verbruggen C, Nussbaumer P, Ovaa H, van der Stelt M, Simonsen KB, Tagmose L, Waldmann H, Duffy J, Finsinger D, Jurzak M, Burgess-Brown NA, Lee WH, Rutjes FPJT, Haag H, Kallus C, Mors H, Dorval T, Lesur B, Ramon Olayo F, Hamza D, Jones G, Pearce C, Piechot A, Tzalis D, Clausen MH, Davis J, Derouane D, Vermeiren C, Kaiser M, Stockman RA, Barrault DV, Pannifer AD, Swedlow JR, Nelson AS, Orru RVA, Ruijter E, van Helden SP, Li VM, Vries T, de Vlieger JSB. Jones PS, et al. Among authors: folmer rha. Nat Rev Drug Discov. 2022 Apr;21(4):245-246. doi: 10.1038/d41573-021-00196-3. Nat Rev Drug Discov. 2022. PMID: 34907316 No abstract available.
Bivalent Ligands for Protein Degradation in Drug Discovery.
Scheepstra M, Hekking KFW, van Hijfte L, Folmer RHA. Scheepstra M, et al. Among authors: folmer rha. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176. doi: 10.1016/j.csbj.2019.01.006. eCollection 2019. Comput Struct Biotechnol J. 2019. PMID: 30788082 Free PMC article. Review.
Unified Software Solution for Efficient SPR Data Analysis in Drug Research.
Dahl G, Steigele S, Hillertz P, Tigerström A, Egnéus A, Mehrle A, Ginkel M, Edfeldt F, Holdgate G, O'Connell N, Kappler B, Brodte A, Rawlins PB, Davies G, Westberg EL, Folmer RH, Heyse S. Dahl G, et al. SLAS Discov. 2017 Feb;22(2):203-209. doi: 10.1177/1087057116675316. Epub 2016 Oct 28. SLAS Discov. 2017. PMID: 27789754 Free PMC article.
Application of fragment-based lead generation to the discovery of novel, cyclic amidine beta-secretase inhibitors with nanomolar potency, cellular activity, and high ligand efficiency.
Edwards PD, Albert JS, Sylvester M, Aharony D, Andisik D, Callaghan O, Campbell JB, Carr RA, Chessari G, Congreve M, Frederickson M, Folmer RH, Geschwindner S, Koether G, Kolmodin K, Krumrine J, Mauger RC, Murray CW, Olsson LL, Patel S, Spear N, Tian G. Edwards PD, et al. J Med Chem. 2007 Nov 29;50(24):5912-25. doi: 10.1021/jm070829p. Epub 2007 Nov 7. J Med Chem. 2007. PMID: 17985862
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