Cash JN - Search Results

1

Structural and biochemical characterization of the pleckstrin homology domain of the RhoGEF P-Rex2 and its regulation by PIP₃.

Cash JN, Sharma PV, Tesmer JJG. Cash JN, et al. J Struct Biol X. 2018 Dec 10;1:100001. doi: 10.1016/j.yjsbx.2018.100001. eCollection 2019 Jan-Mar. J Struct Biol X. 2018. PMID: 34958187 Free PMC article.

2

Structural and Biochemical Characterization of the Catalytic Core of the Metastatic Factor P-Rex1 and Its Regulation by PtdIns(3,4,5)P3.

Cash JN, Davis EM, Tesmer JJG. Cash JN, et al. Structure. 2016 May 3;24(5):730-740. doi: 10.1016/j.str.2016.02.022. Epub 2016 Apr 14. Structure. 2016. PMID: 27150042 Free PMC article.

3

Cryo-electron microscopy structure and analysis of the P-Rex1-Gβγ signaling scaffold.

Cash JN, Urata S, Li S, Ravala SK, Avramova LV, Shost MD, Gutkind JS, Tesmer JJG, Cianfrocco MA. Cash JN, et al. Sci Adv. 2019 Oct 16;5(10):eaax8855. doi: 10.1126/sciadv.aax8855. eCollection 2019 Oct. Sci Adv. 2019. PMID: 31663027 Free PMC article.

4

Discovery of Small Molecules That Target the Phosphatidylinositol (3,4,5) Trisphosphate (PIP₃)-Dependent Rac Exchanger 1 (P-Rex1) PIP₃-Binding Site and Inhibit P-Rex1-Dependent Functions in Neutrophils.

Cash JN, Chandan NR, Hsu AY, Sharma PV, Deng Q, Smrcka AV, Tesmer JJG. Cash JN, et al. Mol Pharmacol. 2020 Mar;97(3):226-236. doi: 10.1124/mol.119.117556. Epub 2020 Jan 3. Mol Pharmacol. 2020. PMID: 31900312 Free PMC article.

5

The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding.

Ravala SK, Hopkins JB, Plescia CB, Allgood SR, Kane MA, Cash JN, Stahelin RV, Tesmer JJG. Ravala SK, et al. Among authors: cash jn. J Biol Chem. 2020 Sep 4;295(36):12635-12647. doi: 10.1074/jbc.RA120.014534. Epub 2020 Jul 13. J Biol Chem. 2020. PMID: 32661198 Free PMC article.

6

High-Throughput Cryo-EM Enabled by User-Free Preprocessing Routines.

Li Y, Cash JN, Tesmer JJG, Cianfrocco MA. Li Y, et al. Among authors: cash jn. Structure. 2020 Jul 7;28(7):858-869.e3. doi: 10.1016/j.str.2020.03.008. Epub 2020 Apr 14. Structure. 2020. PMID: 32294468 Free PMC article.

7

[No title available]

[No authors listed] [No authors listed] PMID: 35552346

8

Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1.

Bandekar SJ, Chen CL, Ravala SK, Cash JN, Avramova LV, Zhalnina MV, Gutkind JS, Li S, Tesmer JJG. Bandekar SJ, et al. Among authors: cash jn. J Biol Chem. 2022 Aug;298(8):102209. doi: 10.1016/j.jbc.2022.102209. Epub 2022 Jun 30. J Biol Chem. 2022. PMID: 35779635 Free PMC article.

9

Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma.

Lu TW, Aoto PC, Weng JH, Nielsen C, Cash JN, Hall J, Zhang P, Simon SM, Cianfrocco MA, Taylor SS. Lu TW, et al. Among authors: cash jn. PLoS Biol. 2020 Dec 28;18(12):e3001018. doi: 10.1371/journal.pbio.3001018. eCollection 2020 Dec. PLoS Biol. 2020. PMID: 33370777 Free PMC article.

10

High-resolution cryo-EM using beam-image shift at 200 keV.

Cash JN, Kearns S, Li Y, Cianfrocco MA. Cash JN, et al. IUCrJ. 2020 Oct 29;7(Pt 6):1179-1187. doi: 10.1107/S2052252520013482. eCollection 2020 Nov 1. IUCrJ. 2020. PMID: 33209328 Free PMC article.

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