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Lysoptosis is an evolutionarily conserved cell death pathway moderated by intracellular serpins.
Luke CJ, Markovina S, Good M, Wight IE, Thomas BJ, Linneman JM, Lanik WE, Koroleva O, Coffman MR, Miedel MT, Gong Q, Andress A, Campos Guerrero M, Wang S, Chen L, Beatty WL, Hausmann KN, White FV, Fitzpatrick JAJ, Orvedahl A, Pak SC, Silverman GA. Luke CJ, et al. Among authors: miedel mt. Commun Biol. 2022 Jan 12;5(1):47. doi: 10.1038/s42003-021-02953-x. Commun Biol. 2022. PMID: 35022507 Free PMC article.
Using C. elegans to identify the protease targets of serpins in vivo.
Bhatia SR, Miedel MT, Chotoo CK, Graf NJ, Hood BL, Conrads TP, Silverman GA, Luke CJ. Bhatia SR, et al. Among authors: miedel mt. Methods Enzymol. 2011;499:283-99. doi: 10.1016/B978-0-12-386471-0.00014-6. Methods Enzymol. 2011. PMID: 21683259 Free PMC article.
A C. elegans model of human α1-antitrypsin deficiency links components of the RNAi pathway to misfolded protein turnover.
Long OS, Benson JA, Kwak JH, Luke CJ, Gosai SJ, O'Reilly LP, Wang Y, Li J, Vetica AC, Miedel MT, Stolz DB, Watkins SC, Züchner S, Perlmutter DH, Silverman GA, Pak SC. Long OS, et al. Among authors: miedel mt. Hum Mol Genet. 2014 Oct 1;23(19):5109-22. doi: 10.1093/hmg/ddu235. Epub 2014 May 16. Hum Mol Genet. 2014. PMID: 24838286 Free PMC article.
SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin.
Niehaus JZ, Miedel MT, Good M, Wyatt AN, Pak SC, Silverman GA, Luke CJ. Niehaus JZ, et al. Among authors: miedel mt. Biochemistry. 2015 Nov 17;54(45):6756-9. doi: 10.1021/acs.biochem.5b01042. Epub 2015 Nov 5. Biochemistry. 2015. PMID: 26497600 Free PMC article.
24 results