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Gestational Insulin Resistance Is Mediated by the Gut Microbiome-Indoleamine 2,3-Dioxygenase Axis.
Priyadarshini M, Navarro G, Reiman DJ, Sharma A, Xu K, Lednovich K, Manzella CR, Khan MW, Garcia MS, Allard S, Wicksteed B, Chlipala GE, Szynal B, Bernabe BP, Maki PM, Gill RK, Perdew GH, Gilbert J, Dai Y, Layden BT. Priyadarshini M, et al. Among authors: layden bt. Gastroenterology. 2022 May;162(6):1675-1689.e11. doi: 10.1053/j.gastro.2022.01.008. Epub 2022 Jan 13. Gastroenterology. 2022. PMID: 35032499 Free PMC article.
HKDC1, a target of TFEB, is essential to maintain both mitochondrial and lysosomal homeostasis, preventing cellular senescence.
Cui M, Yamano K, Yamamoto K, Yamamoto-Imoto H, Minami S, Yamamoto T, Matsui S, Kaminishi T, Shima T, Ogura M, Tsuchiya M, Nishino K, Layden BT, Kato H, Ogawa H, Oki S, Okada Y, Isaka Y, Kosako H, Matsuda N, Yoshimori T, Nakamura S. Cui M, et al. Among authors: layden bt. Proc Natl Acad Sci U S A. 2024 Jan 9;121(2):e2306454120. doi: 10.1073/pnas.2306454120. Epub 2024 Jan 3. Proc Natl Acad Sci U S A. 2024. PMID: 38170752
An Acetate-Specific GPCR, FFAR2, Regulates Insulin Secretion.
Priyadarshini M, Villa SR, Fuller M, Wicksteed B, Mackay CR, Alquier T, Poitout V, Mancebo H, Mirmira RG, Gilchrist A, Layden BT. Priyadarshini M, et al. Among authors: layden bt. Mol Endocrinol. 2015 Jul;29(7):1055-66. doi: 10.1210/me.2015-1007. Epub 2015 Jun 15. Mol Endocrinol. 2015. PMID: 26075576 Free PMC article.
The short-chain fatty acid receptor, FFA2, contributes to gestational glucose homeostasis.
Fuller M, Priyadarshini M, Gibbons SM, Angueira AR, Brodsky M, Hayes MG, Kovatcheva-Datchary P, Bäckhed F, Gilbert JA, Lowe WL Jr, Layden BT. Fuller M, et al. Among authors: layden bt. Am J Physiol Endocrinol Metab. 2015 Nov 15;309(10):E840-51. doi: 10.1152/ajpendo.00171.2015. Epub 2015 Sep 22. Am J Physiol Endocrinol Metab. 2015. PMID: 26394664 Free PMC article.
The obese gut microbiome across the epidemiologic transition.
Dugas LR, Fuller M, Gilbert J, Layden BT. Dugas LR, et al. Among authors: layden bt. Emerg Themes Epidemiol. 2016 Jan 11;13:2. doi: 10.1186/s12982-015-0044-5. eCollection 2016. Emerg Themes Epidemiol. 2016. PMID: 26759600 Free PMC article. Review.
SCFA Receptors in Pancreatic β Cells: Novel Diabetes Targets?
Priyadarshini M, Wicksteed B, Schiltz GE, Gilchrist A, Layden BT. Priyadarshini M, et al. Among authors: layden bt. Trends Endocrinol Metab. 2016 Sep;27(9):653-664. doi: 10.1016/j.tem.2016.03.011. Epub 2016 Apr 15. Trends Endocrinol Metab. 2016. PMID: 27091493 Free PMC article. Review.
115 results