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Transition to invasive breast cancer is associated with progressive changes in the structure and composition of tumor stroma.
Risom T, Glass DR, Averbukh I, Liu CC, Baranski A, Kagel A, McCaffrey EF, Greenwald NF, Rivero-Gutiérrez B, Strand SH, Varma S, Kong A, Keren L, Srivastava S, Zhu C, Khair Z, Veis DJ, Deschryver K, Vennam S, Maley C, Hwang ES, Marks JR, Bendall SC, Colditz GA, West RB, Angelo M. Risom T, et al. Cell. 2022 Jan 20;185(2):299-310.e18. doi: 10.1016/j.cell.2021.12.023. Cell. 2022. PMID: 35063072 Free PMC article.
MIBI-TOF: A multiplexed imaging platform relates cellular phenotypes and tissue structure.
Keren L, Bosse M, Thompson S, Risom T, Vijayaragavan K, McCaffrey E, Marquez D, Angoshtari R, Greenwald NF, Fienberg H, Wang J, Kambham N, Kirkwood D, Nolan G, Montine TJ, Galli SJ, West R, Bendall SC, Angelo M. Keren L, et al. Among authors: risom t. Sci Adv. 2019 Oct 9;5(10):eaax5851. doi: 10.1126/sciadv.aax5851. eCollection 2019 Oct. Sci Adv. 2019. PMID: 31633026 Free PMC article.
Multiplexed Ion Beam Imaging: Insights into Pathobiology.
Liu CC, McCaffrey EF, Greenwald NF, Soon E, Risom T, Vijayaragavan K, Oliveria JP, Mrdjen D, Bosse M, Tebaykin D, Bendall SC, Angelo M. Liu CC, et al. Among authors: risom t. Annu Rev Pathol. 2022 Jan 24;17:403-423. doi: 10.1146/annurev-pathmechdis-030321-091459. Epub 2021 Nov 9. Annu Rev Pathol. 2022. PMID: 34752710 Review.
Whole-cell segmentation of tissue images with human-level performance using large-scale data annotation and deep learning.
Greenwald NF, Miller G, Moen E, Kong A, Kagel A, Dougherty T, Fullaway CC, McIntosh BJ, Leow KX, Schwartz MS, Pavelchek C, Cui S, Camplisson I, Bar-Tal O, Singh J, Fong M, Chaudhry G, Abraham Z, Moseley J, Warshawsky S, Soon E, Greenbaum S, Risom T, Hollmann T, Bendall SC, Keren L, Graf W, Angelo M, Van Valen D. Greenwald NF, et al. Among authors: risom t. Nat Biotechnol. 2022 Apr;40(4):555-565. doi: 10.1038/s41587-021-01094-0. Epub 2021 Nov 18. Nat Biotechnol. 2022. PMID: 34795433 Free PMC article.
MITI minimum information guidelines for highly multiplexed tissue images.
Schapiro D, Yapp C, Sokolov A, Reynolds SM, Chen YA, Sudar D, Xie Y, Muhlich J, Arias-Camison R, Arena S, Taylor AJ, Nikolov M, Tyler M, Lin JR, Burlingame EA; Human Tumor Atlas Network; Chang YH, Farhi SL, Thorsson V, Venkatamohan N, Drewes JL, Pe'er D, Gutman DA, Herrmann MD, Gehlenborg N, Bankhead P, Roland JT, Herndon JM, Snyder MP, Angelo M, Nolan G, Swedlow JR, Schultz N, Merrick DT, Mazzili SA, Cerami E, Rodig SJ, Santagata S, Sorger PK. Schapiro D, et al. Nat Methods. 2022 Mar;19(3):262-267. doi: 10.1038/s41592-022-01415-4. Nat Methods. 2022. PMID: 35277708 Free PMC article.
Differentiation-state plasticity is a targetable resistance mechanism in basal-like breast cancer.
Risom T, Langer EM, Chapman MP, Rantala J, Fields AJ, Boniface C, Alvarez MJ, Kendsersky ND, Pelz CR, Johnson-Camacho K, Dobrolecki LE, Chin K, Aswani AJ, Wang NJ, Califano A, Lewis MT, Tomlin CJ, Spellman PT, Adey A, Gray JW, Sears RC. Risom T, et al. Nat Commun. 2018 Sep 19;9(1):3815. doi: 10.1038/s41467-018-05729-w. Nat Commun. 2018. PMID: 30232459 Free PMC article.
Transcriptional signatures in histologic structures within glioblastoma tumors may predict personalized drug sensitivity and survival.
Kersch CN, Claunch CJ, Ambady P, Bucher E, Schwartz DL, Barajas RF Jr, Iliff JJ, Risom T, Heiser L, Muldoon LL, Korkola JE, Gray JW, Neuwelt EA. Kersch CN, et al. Among authors: risom t. Neurooncol Adv. 2020 Aug 3;2(1):vdaa093. doi: 10.1093/noajnl/vdaa093. eCollection 2020 Jan-Dec. Neurooncol Adv. 2020. PMID: 32904984 Free PMC article.
Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models.
Lin J, Sampath D, Nannini MA, Lee BB, Degtyarev M, Oeh J, Savage H, Guan Z, Hong R, Kassees R, Lee LB, Risom T, Gross S, Liederer BM, Koeppen H, Skelton NJ, Wallin JJ, Belvin M, Punnoose E, Friedman LS, Lin K. Lin J, et al. Among authors: risom t. Clin Cancer Res. 2013 Apr 1;19(7):1760-72. doi: 10.1158/1078-0432.CCR-12-3072. Epub 2013 Jan 3. Clin Cancer Res. 2013. PMID: 23287563
26 results