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Targeting pancreatic cancer by TAK-981: a SUMOylation inhibitor that activates the immune system and blocks cancer cell cycle progression in a preclinical model.
Kumar S, Schoonderwoerd MJA, Kroonen JS, de Graaf IJ, Sluijter M, Ruano D, González-Prieto R, Verlaan-de Vries M, Rip J, Arens R, de Miranda NFCC, Hawinkels LJAC, van Hall T, Vertegaal ACO. Kumar S, et al. Among authors: schoonderwoerd mja. Gut. 2022 Nov;71(11):2266-2283. doi: 10.1136/gutjnl-2021-324834. Epub 2022 Jan 24. Gut. 2022. PMID: 35074907 Free PMC article.
Endoglin: Beyond the Endothelium.
Schoonderwoerd MJA, Goumans MTH, Hawinkels LJAC. Schoonderwoerd MJA, et al. Biomolecules. 2020 Feb 12;10(2):289. doi: 10.3390/biom10020289. Biomolecules. 2020. PMID: 32059544 Free PMC article. Review.
Targeting Endoglin-Expressing Regulatory T Cells in the Tumor Microenvironment Enhances the Effect of PD1 Checkpoint Inhibitor Immunotherapy.
Schoonderwoerd MJA, Koops MFM, Angela RA, Koolmoes B, Toitou M, Paauwe M, Barnhoorn MC, Liu Y, Sier CFM, Hardwick JCH, Nixon AB, Theuer CP, Fransen MF, Hawinkels LJAC. Schoonderwoerd MJA, et al. Clin Cancer Res. 2020 Jul 15;26(14):3831-3842. doi: 10.1158/1078-0432.CCR-19-2889. Epub 2020 Apr 24. Clin Cancer Res. 2020. PMID: 32332012
Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis.
Paauwe M, Schoonderwoerd MJA, Helderman RFCP, Harryvan TJ, Groenewoud A, van Pelt GW, Bor R, Hemmer DM, Versteeg HH, Snaar-Jagalska BE, Theuer CP, Hardwick JCH, Sier CFM, Ten Dijke P, Hawinkels LJAC. Paauwe M, et al. Among authors: schoonderwoerd mja. Clin Cancer Res. 2018 Dec 15;24(24):6331-6344. doi: 10.1158/1078-0432.CCR-18-0329. Epub 2018 Jun 26. Clin Cancer Res. 2018. PMID: 29945992
PD-L1 expression on malignant cells is no prerequisite for checkpoint therapy.
Kleinovink JW, Marijt KA, Schoonderwoerd MJA, van Hall T, Ossendorp F, Fransen MF. Kleinovink JW, et al. Among authors: schoonderwoerd mja. Oncoimmunology. 2017 Feb 21;6(4):e1294299. doi: 10.1080/2162402X.2017.1294299. eCollection 2017. Oncoimmunology. 2017. PMID: 28507803 Free PMC article.
15 results