Spencer HT - Search Results

1

PI3Kδ/γ inhibition promotes human CART cell epigenetic and metabolic reprogramming to enhance antitumor cytotoxicity.

Funk CR, Wang S, Chen KZ, Waller A, Sharma A, Edgar CL, Gupta VA, Chandrakasan S, Zoine JT, Fedanov A, Raikar SS, Koff JL, Flowers CR, Coma S, Pachter JA, Ravindranathan S, Spencer HT, Shanmugam M, Waller EK. Funk CR, et al. Among authors: spencer ht. Blood. 2022 Jan 27;139(4):523-537. doi: 10.1182/blood.2021011597. Blood. 2022. PMID: 35084470 Free PMC article.

2

Hematopoietic stem-cell gene therapy of hemophilia A incorporating a porcine factor VIII transgene and nonmyeloablative conditioning regimens.

Ide LM, Gangadharan B, Chiang KY, Doering CB, Spencer HT. Ide LM, et al. Among authors: spencer ht. Blood. 2007 Oct 15;110(8):2855-63. doi: 10.1182/blood-2007-04-082602. Epub 2007 Jun 14. Blood. 2007. PMID: 17569821 Free PMC article.

3

Genetic engineering of chimeric antigen receptors using lamprey derived variable lymphocyte receptors.

Moot R, Raikar SS, Fleischer L, Querrey M, Tylawsky DE, Nakahara H, Doering CB, Spencer HT. Moot R, et al. Among authors: spencer ht. Mol Ther Oncolytics. 2016 Dec 7;3:16026. doi: 10.1038/mto.2016.26. eCollection 2016. Mol Ther Oncolytics. 2016. PMID: 27933313 Free PMC article.

4

Improving T-cell expansion and function for adoptive T-cell therapy using ex vivo treatment with PI3Kδ inhibitors and VIP antagonists.

Petersen CT, Hassan M, Morris AB, Jeffery J, Lee K, Jagirdar N, Staton AD, Raikar SS, Spencer HT, Sulchek T, Flowers CR, Waller EK. Petersen CT, et al. Among authors: spencer ht. Blood Adv. 2018 Feb 13;2(3):210-223. doi: 10.1182/bloodadvances.2017011254. Blood Adv. 2018. PMID: 29386194 Free PMC article.

5

Development of chimeric antigen receptors targeting T-cell malignancies using two structurally different anti-CD5 antigen binding domains in NK and CRISPR-edited T cell lines.

Raikar SS, Fleischer LC, Moot R, Fedanov A, Paik NY, Knight KA, Doering CB, Spencer HT. Raikar SS, et al. Among authors: spencer ht. Oncoimmunology. 2017 Dec 26;7(3):e1407898. doi: 10.1080/2162402X.2017.1407898. eCollection 2018. Oncoimmunology. 2017. PMID: 29399409 Free PMC article.

6

Ex vivo expanded patient-derived γδ T-cell immunotherapy enhances neuroblastoma tumor regression in a murine model.

Zoine JT, Knight KA, Fleischer LC, Sutton KS, Goldsmith KC, Doering CB, Spencer HT. Zoine JT, et al. Among authors: spencer ht. Oncoimmunology. 2019 May 27;8(8):1593804. doi: 10.1080/2162402X.2019.1593804. eCollection 2019. Oncoimmunology. 2019. PMID: 31413905 Free PMC article.

7

The 3.2 Å structure of a bioengineered variant of blood coagulation factor VIII indicates two conformations of the C2 domain.

Smith IW, d'Aquino AE, Coyle CW, Fedanov A, Parker ET, Denning G, Spencer HT, Lollar P, Doering CB, Spiegel PC Jr. Smith IW, et al. Among authors: spencer ht. J Thromb Haemost. 2020 Jan;18(1):57-69. doi: 10.1111/jth.14621. Epub 2019 Sep 8. J Thromb Haemost. 2020. PMID: 31454152 Free PMC article.

8

Targeting T cell malignancies using CAR-based immunotherapy: challenges and potential solutions.

Fleischer LC, Spencer HT, Raikar SS. Fleischer LC, et al. Among authors: spencer ht. J Hematol Oncol. 2019 Dec 29;12(1):141. doi: 10.1186/s13045-019-0801-y. J Hematol Oncol. 2019. PMID: 31884955 Free PMC article. Review.

9

Lentiviral Gene Therapy for Familial Hemophagocytic Lymphohistiocytosis Type 3, Caused by UNC13D Genetic Defects.

Takushi SE, Paik NY, Fedanov A, Prince C, Doering CB, Spencer HT, Chandrakasan S. Takushi SE, et al. Among authors: spencer ht. Hum Gene Ther. 2020 Jun;31(11-12):626-638. doi: 10.1089/hum.2019.329. Hum Gene Ther. 2020. PMID: 32253931 Free PMC article.

10

Non-signaling Chimeric Antigen Receptors Enhance Antigen-Directed Killing by γδ T Cells in Contrast to αβ T Cells.

Fleischer LC, Becker SA, Ryan RE, Fedanov A, Doering CB, Spencer HT. Fleischer LC, et al. Among authors: spencer ht. Mol Ther Oncolytics. 2020 Jun 4;18:149-160. doi: 10.1016/j.omto.2020.06.003. eCollection 2020 Sep 25. Mol Ther Oncolytics. 2020. PMID: 32671190 Free PMC article.

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