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127 results

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mRNA-LNP prime boost evolves precursors toward VRC01-like broadly neutralizing antibodies in preclinical humanized mouse models.
Wang X, Cottrell CA, Hu X, Ray R, Bottermann M, Villavicencio PM, Yan Y, Xie Z, Warner JE, Ellis-Pugh JR, Kalyuzhniy O, Liguori A, Willis JR, Menis S, Rämisch S, Eskandarzadeh S, Kubitz M, Tingle R, Phelps N, Groschel B, Himansu S, Carfi A, Kirsch KH, Weldon SR, Nair U, Schief WR, Batista FD. Wang X, et al. Among authors: carfi a. Sci Immunol. 2024 May 10;9(95):eadn0622. doi: 10.1126/sciimmunol.adn0622. Epub 2024 May 16. Sci Immunol. 2024. PMID: 38753808
mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies.
Xie Z, Lin YC, Steichen JM, Ozorowski G, Kratochvil S, Ray R, Torres JL, Liguori A, Kalyuzhniy O, Wang X, Warner JE, Weldon SR, Dale GA, Kirsch KH, Nair U, Baboo S, Georgeson E, Adachi Y, Kubitz M, Jackson AM, Richey ST, Volk RM, Lee JH, Diedrich JK, Prum T, Falcone S, Himansu S, Carfi A, Yates JR 3rd, Paulson JC, Sok D, Ward AB, Schief WR, Batista FD. Xie Z, et al. Among authors: carfi a. Science. 2024 May 17;384(6697):eadk0582. doi: 10.1126/science.adk0582. Epub 2024 May 17. Science. 2024. PMID: 38753770
Vaccination for healthy aging.
Bloom DE, Pecetta S, Scorza FB, Carfi A, Carleton B, Cipriano M, Edwards K, Gasperini G, Malley R, Nandi A, Nguyen A, Stuart L, Black S, Rappuoli R. Bloom DE, et al. Among authors: carfi a. Sci Transl Med. 2024 May;16(745):eadm9183. doi: 10.1126/scitranslmed.adm9183. Epub 2024 May 1. Sci Transl Med. 2024. PMID: 38691620 Review.
Human Cytomegalovirus mRNA-1647 Vaccine Candidate Elicits Potent and Broad Neutralization and Higher Antibody-Dependent Cellular Cytotoxicity Responses Than the gB/MF59 Vaccine.
Hu X, Karthigeyan KP, Herbek S, Valencia SM, Jenks JA, Webster H, Miller IG, Connors M, Pollara J, Andy C, Gerber LM, Walter EB, Edwards KM, Bernstein DI, Hou J, Koch M, Panther L, Carfi A, Wu K, Permar SR. Hu X, et al. Among authors: carfi a. J Infect Dis. 2024 Feb 7:jiad593. doi: 10.1093/infdis/jiad593. Online ahead of print. J Infect Dis. 2024. PMID: 38324766
Interaction dynamics between innate and adaptive immune cells responding to SARS-CoV-2 vaccination in non-human primates.
Schramm CA, Moon D, Peyton L, Lima NS, Wake C, Boswell KL, Henry AR, Laboune F, Ambrozak D, Darko SW, Teng IT, Foulds KE, Carfi A, Edwards DK, Kwong PD, Koup RA, Seder RA, Douek DC. Schramm CA, et al. Among authors: carfi a. Nat Commun. 2023 Dec 2;14(1):7961. doi: 10.1038/s41467-023-43420-x. Nat Commun. 2023. PMID: 38042809 Free PMC article.
An mRNA-based platform for the delivery of pathogen-specific IgA into mucosal secretions.
Deal CE, Richards AF, Yeung T, Maron MJ, Wang Z, Lai YT, Fritz BR, Himansu S, Narayanan E, Liu D, Koleva R, Licht S, Hsiao CJ, Rajlic IL, Koch H, Kleyman M, Pulse ME, Weiss WJ, Doering JE, Lindberg SK, Mantis NJ, Carfi A, Plante OJ. Deal CE, et al. Among authors: carfi a. Cell Rep Med. 2023 Nov 21;4(11):101253. doi: 10.1016/j.xcrm.2023.101253. Epub 2023 Nov 1. Cell Rep Med. 2023. PMID: 37918405 Free PMC article.
An mpox virus mRNA-lipid nanoparticle vaccine confers protection against lethal orthopoxviral challenge.
Freyn AW, Atyeo C, Earl PL, Americo JL, Chuang GY, Natarajan H, Frey TR, Gall JG, Moliva JI, Hunegnaw R, Asthagiri Arunkumar G, Ogega CO, Nasir A, Santos G, Levin RH, Meni A, Jorquera PA, Bennett H, Johnson JA, Durney MA, Stewart-Jones G, Hooper JW, Colpitts TM, Alter G, Sullivan NJ, Carfi A, Moss B. Freyn AW, et al. Among authors: carfi a. Sci Transl Med. 2023 Oct 4;15(716):eadg3540. doi: 10.1126/scitranslmed.adg3540. Epub 2023 Oct 4. Sci Transl Med. 2023. PMID: 37792954
127 results