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Sirt6 regulates lifespan in Drosophila melanogaster.
Taylor JR, Wood JG, Mizerak E, Hinthorn S, Liu J, Finn M, Gordon S, Zingas L, Chang C, Klein MA, Denu JM, Gorbunova V, Seluanov A, Boeke JD, Sedivy JM, Helfand SL. Taylor JR, et al. Among authors: denu jm. Proc Natl Acad Sci U S A. 2022 Feb 1;119(5):e2111176119. doi: 10.1073/pnas.2111176119. Proc Natl Acad Sci U S A. 2022. PMID: 35091469 Free PMC article.
Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases.
Hallows WC, Lee S, Denu JM. Hallows WC, et al. Among authors: denu jm. Proc Natl Acad Sci U S A. 2006 Jul 5;103(27):10230-10235. doi: 10.1073/pnas.0604392103. Epub 2006 Jun 21. Proc Natl Acad Sci U S A. 2006. PMID: 16790548 Free PMC article.
Catalytic activation of histone acetyltransferase Rtt109 by a histone chaperone.
Kolonko EM, Albaugh BN, Lindner SE, Chen Y, Satyshur KA, Arnold KM, Kaufman PD, Keck JL, Denu JM. Kolonko EM, et al. Among authors: denu jm. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20275-80. doi: 10.1073/pnas.1009860107. Epub 2010 Nov 5. Proc Natl Acad Sci U S A. 2010. PMID: 21057107 Free PMC article.
An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.
Ferrer CM, Alders M, Postma AV, Park S, Klein MA, Cetinbas M, Pajkrt E, Glas A, van Koningsbruggen S, Christoffels VM, Mannens MMAM, Knegt L, Etchegaray JP, Sadreyev RI, Denu JM, Mostoslavsky G, van Maarle MC, Mostoslavsky R. Ferrer CM, et al. Among authors: denu jm. Genes Dev. 2018 Mar 1;32(5-6):373-388. doi: 10.1101/gad.307330.117. Epub 2018 Mar 19. Genes Dev. 2018. PMID: 29555651 Free PMC article.
Mechanism of activation for the sirtuin 6 protein deacylase.
Klein MA, Liu C, Kuznetsov VI, Feltenberger JB, Tang W, Denu JM. Klein MA, et al. Among authors: denu jm. J Biol Chem. 2020 Jan 31;295(5):1385-1399. doi: 10.1074/jbc.RA119.011285. Epub 2019 Dec 10. J Biol Chem. 2020. PMID: 31822559 Free PMC article.
204 results