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BACE1: More than just a β-secretase.
Taylor HA, Przemylska L, Clavane EM, Meakin PJ. Taylor HA, et al. Among authors: meakin pj. Obes Rev. 2022 Jul;23(7):e13430. doi: 10.1111/obr.13430. Epub 2022 Feb 4. Obes Rev. 2022. PMID: 35119166 Free PMC article. Review.
Endothelial Cell Fibrin Gel Angiogenesis Bead Assay.
Clavane EM, Taylor HA, Cubbon RM, Meakin PJ. Clavane EM, et al. Among authors: meakin pj. Methods Mol Biol. 2022;2441:321-327. doi: 10.1007/978-1-0716-2059-5_25. Methods Mol Biol. 2022. PMID: 35099748
Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction.
Meakin PJ, Coull BM, Tuharska Z, McCaffery C, Akoumianakis I, Antoniades C, Brown J, Griffin KJ, Platt F, Ozber CH, Yuldasheva NY, Makava N, Skromna A, Prescott A, McNeilly AD, Siddiqui M, Palmer CN, Khan F, Ashford ML. Meakin PJ, et al. J Clin Invest. 2020 Aug 3;130(8):4104-4117. doi: 10.1172/JCI122237. J Clin Invest. 2020. PMID: 32407295 Free PMC article.
The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling.
Botteri G, Salvadó L, Gumà A, Lee Hamilton D, Meakin PJ, Montagut G, Ashford MLJ, Ceperuelo-Mallafré V, Fernández-Veledo S, Vendrell J, Calderón-Dominguez M, Serra D, Herrero L, Pizarro J, Barroso E, Palomer X, Vázquez-Carrera M. Botteri G, et al. Among authors: meakin pj. Metabolism. 2018 Aug;85:59-75. doi: 10.1016/j.metabol.2018.03.005. Epub 2018 Mar 9. Metabolism. 2018. PMID: 29526536 Free article.
29 results