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Immune-stimulating antibody conjugates elicit robust myeloid activation and durable antitumor immunity.
Ackerman SE, Pearson CI, Gregorio JD, Gonzalez JC, Kenkel JA, Hartmann FJ, Luo A, Ho PY, LeBlanc H, Blum LK, Kimmey SC, Luo A, Nguyen ML, Paik JC, Sheu LY, Ackerman B, Lee A, Li H, Melrose J, Laura RP, Ramani VC, Henning KA, Jackson DY, Safina BS, Yonehiro G, Devens BH, Carmi Y, Chapin SJ, Bendall SC, Kowanetz M, Dornan D, Engleman EG, Alonso MN. Ackerman SE, et al. Among authors: devens bh. Nat Cancer. 2021 Jan;2(1):18-33. doi: 10.1038/s43018-020-00136-x. Epub 2020 Dec 7. Nat Cancer. 2021. PMID: 35121890 Free PMC article.
The Effect of ASP2409, a Novel CD86-Selective Variant of CTLA4-Ig, on Renal Allograft Rejection in Nonhuman Primates.
Oshima S, Karrer EE, Kawato Y, Maeda M, Fukahori H, Tsujimoto S, Hirose J, Nakamura K, Marui T, Takamura F, Noto T, Chapin SJ, Fujii Y, Neighbors M, Viswanathan S, Devens BH, Higashi Y. Oshima S, et al. Among authors: devens bh. Transplantation. 2016 Dec;100(12):2611-2620. doi: 10.1097/TP.0000000000001397. Transplantation. 2016. PMID: 27861289
ASP2408 and ASP2409, novel CTLA4-Ig variants with CD86-selective ligand binding activity and improved immunosuppressive potency, created by directed evolution.
Oshima S, Karrer EE, Paidhungat MM, Neighbors M, Chapin SJ, Fan RA, Reed MA, Wu K, Wong C, Chen Y, Whitlow M, Anderson FA, Bam RA, Zhang Q, Larsen BR, Viswanathan S, Devens BH, Bass SH, Higashi Y. Oshima S, et al. Among authors: devens bh. Protein Eng Des Sel. 2016 May;29(5):159-67. doi: 10.1093/protein/gzw002. Epub 2016 Mar 10. Protein Eng Des Sel. 2016. PMID: 26968452
39 results