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Engineering SARS-CoV-2 cocktail antibodies into a bispecific format improves neutralizing potency and breadth.
Ku Z, Xie X, Lin J, Gao P, El Sahili A, Su H, Liu Y, Ye X, Li X, Fan X, Goh BC, Xiong W, Boyd H, Muruato AE, Deng H, Xia H, Jing Z, Kalveram BK, Menachery VD, Zhang N, Lescar J, Shi PY, An Z. Ku Z, et al. Among authors: lescar j. bioRxiv [Preprint]. 2022 Feb 1:2022.02.01.478504. doi: 10.1101/2022.02.01.478504. bioRxiv. 2022. PMID: 35132410 Free PMC article. Updated. Preprint.
Functional analysis of two cavities in flavivirus NS5 polymerase.
Zou G, Chen YL, Dong H, Lim CC, Yap LJ, Yau YH, Shochat SG, Lescar J, Shi PY. Zou G, et al. Among authors: lescar j. J Biol Chem. 2011 Apr 22;286(16):14362-72. doi: 10.1074/jbc.M110.214189. Epub 2011 Feb 23. J Biol Chem. 2011. PMID: 21349834 Free PMC article.
A crystal structure of the dengue virus non-structural protein 5 (NS5) polymerase delineates interdomain amino acid residues that enhance its thermostability and de novo initiation activities.
Lim SP, Koh JH, Seh CC, Liew CW, Davidson AD, Chua LS, Chandrasekaran R, Cornvik TC, Shi PY, Lescar J. Lim SP, et al. Among authors: lescar j. J Biol Chem. 2013 Oct 25;288(43):31105-14. doi: 10.1074/jbc.M113.508606. Epub 2013 Sep 11. J Biol Chem. 2013. PMID: 24025331 Free PMC article.
Mapping the Interactions between the NS4B and NS3 proteins of dengue virus.
Zou J, Lee le T, Wang QY, Xie X, Lu S, Yau YH, Yuan Z, Geifman Shochat S, Kang C, Lescar J, Shi PY. Zou J, et al. Among authors: lescar j. J Virol. 2015 Apr;89(7):3471-83. doi: 10.1128/JVI.03454-14. Epub 2015 Jan 14. J Virol. 2015. PMID: 25589636 Free PMC article.
178 results