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A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions.
Liu Y, Zhang X, Liu J, Xia H, Zou J, Muruato AE, Periasamy S, Plante JA, Bopp NE, Kurhade C, Bukreyev A, Ren P, Wang T, Menachery VD, Plante KS, Xie X, Weaver SC, Shi PY. Liu Y, et al. Among authors: xie x. bioRxiv [Preprint]. 2022 Feb 15:2022.02.14.480460. doi: 10.1101/2022.02.14.480460. bioRxiv. 2022. PMID: 35194609 Free PMC article. Updated. Preprint.
Mouse Adapted SARS-CoV-2 protects animals from lethal SARS-CoV challenge.
Muruato A, Vu MN, Johnson BA, Davis-Gardner ME, Vanderheiden A, Lokugmage K, Schindewolf C, Crocquet-Valdes PA, Langsjoen RM, Plante JA, Plante KS, Weaver SC, Debbink K, Routh AL, Walker D, Suthar MS, Xie X, Shi PY, Xie X, Menachery VD. Muruato A, et al. Among authors: xie x. bioRxiv [Preprint]. 2021 May 4:2021.05.03.442357. doi: 10.1101/2021.05.03.442357. bioRxiv. 2021. PMID: 33972939 Free PMC article. Updated. Preprint.
Nucleocapsid mutations in SARS-CoV-2 augment replication and pathogenesis.
Johnson BA, Zhou Y, Lokugamage KG, Vu MN, Bopp N, Crocquet-Valdes PA, Kalveram B, Schindewolf C, Liu Y, Scharton D, Plante JA, Xie X, Aguilar P, Weaver SC, Shi PY, Walker DH, Routh AL, Plante KS, Menachery VD. Johnson BA, et al. Among authors: xie x. bioRxiv [Preprint]. 2022 Mar 28:2021.10.14.464390. doi: 10.1101/2021.10.14.464390. bioRxiv. 2022. PMID: 34671771 Free PMC article. Updated. Preprint.
A modified porous silicon microparticle promotes mucosal delivery of SARS-CoV-2 antigen and induction of potent and durable systemic and mucosal T helper 1 skewed protective immunity.
Adam A, Shi Q, Wang B, Zou J, Mai J, Osman SR, Wu W, Xie X, Aguilar PV, Bao X, Shi PY, Shen H, Wang T. Adam A, et al. Among authors: xie x. bioRxiv [Preprint]. 2021 Nov 24:2021.11.22.469576. doi: 10.1101/2021.11.22.469576. bioRxiv. 2021. PMID: 34845456 Free PMC article. Preprint.
Engineering SARS-CoV-2 cocktail antibodies into a bispecific format improves neutralizing potency and breadth.
Ku Z, Xie X, Lin J, Gao P, El Sahili A, Su H, Liu Y, Ye X, Li X, Fan X, Goh BC, Xiong W, Boyd H, Muruato AE, Deng H, Xia H, Jing Z, Kalveram BK, Menachery VD, Zhang N, Lescar J, Shi PY, An Z. Ku Z, et al. Among authors: xie x. bioRxiv [Preprint]. 2022 Feb 1:2022.02.01.478504. doi: 10.1101/2022.02.01.478504. bioRxiv. 2022. PMID: 35132410 Free PMC article. Updated. Preprint.
Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main Protease.
Alugubelli YR, Xiao J, Khatua K, Kumar S, Sun L, Ma Y, Ma XR, Vulupala VR, Atla S, Blankenship LR, Coleman D, Xie X, Neuman BW, Liu WR, Xu S. Alugubelli YR, et al. Among authors: xie x. J Med Chem. 2024 Apr 25;67(8):6495-6507. doi: 10.1021/acs.jmedchem.3c02416. Epub 2024 Apr 12. J Med Chem. 2024. PMID: 38608245 Free PMC article.
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