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Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages.
Runtsch MC, Angiari S, Hooftman A, Wadhwa R, Zhang Y, Zheng Y, Spina JS, Ruzek MC, Argiriadi MA, McGettrick AF, Mendez RS, Zotta A, Peace CG, Walsh A, Chirillo R, Hams E, Fallon PG, Jayamaran R, Dua K, Brown AC, Kim RY, Horvat JC, Hansbro PM, Wang C, O'Neill LAJ. Runtsch MC, et al. Among authors: mendez rs. Cell Metab. 2022 Mar 1;34(3):487-501.e8. doi: 10.1016/j.cmet.2022.02.002. Cell Metab. 2022. PMID: 35235776 Free article.
Adalimumab for refractory peripheral ulcerative keratitis.
Cordero-Coma M, Méndez RS, Blanco AC, Corral AL, Calleja-Antolín S, de Morales JM. Cordero-Coma M, et al. Among authors: mendez rs. J Ophthalmic Inflamm Infect. 2012 Dec;2(4):227-9. doi: 10.1007/s12348-012-0080-z. Epub 2012 May 16. J Ophthalmic Inflamm Infect. 2012. PMID: 22588776 Free PMC article. No abstract available.