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Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S.
Harryvan TJ, Visser M, de Bruin L, Plug L, Griffioen L, Mulder A, van Veelen PA, van der Heden van Noort GJ, Jongsma ML, Meeuwsen MH, Wiertz EJ, Santegoets SJ, Hardwick JC, Van Hall T, Neefjes J, Van der Burg SH, Hawinkels LJ, Verdegaal EM. Harryvan TJ, et al. Among authors: hardwick jc. J Immunother Cancer. 2022 Mar;10(3):e003591. doi: 10.1136/jitc-2021-003591. J Immunother Cancer. 2022. PMID: 35264435 Free PMC article.
The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC.
Voorneveld PW, Kodach LL, Jacobs RJ, van Noesel CJ, Peppelenbosch MP, Korkmaz KS, Molendijk I, Dekker E, Morreau H, van Pelt GW, Tollenaar RA, Mesker W, Hawinkels LJ, Paauwe M, Verspaget HW, Geraets DT, Hommes DW, Offerhaus GJ, van den Brink GR, Ten Dijke P, Hardwick JC. Voorneveld PW, et al. Among authors: hardwick jc. Br J Cancer. 2015 Jan 6;112(1):122-30. doi: 10.1038/bjc.2014.560. Epub 2014 Nov 13. Br J Cancer. 2015. PMID: 25393365 Free PMC article.
Putting the Wnt up colon cancer.
Hawinkels LJ, Hardwick JC. Hawinkels LJ, et al. Among authors: hardwick jc. Gut. 2017 Jun;66(6):983-984. doi: 10.1136/gutjnl-2016-312584. Epub 2016 Nov 10. Gut. 2017. PMID: 28501817 No abstract available.
Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis.
Paauwe M, Schoonderwoerd MJA, Helderman RFCP, Harryvan TJ, Groenewoud A, van Pelt GW, Bor R, Hemmer DM, Versteeg HH, Snaar-Jagalska BE, Theuer CP, Hardwick JCH, Sier CFM, Ten Dijke P, Hawinkels LJAC. Paauwe M, et al. Clin Cancer Res. 2018 Dec 15;24(24):6331-6344. doi: 10.1158/1078-0432.CCR-18-0329. Epub 2018 Jun 26. Clin Cancer Res. 2018. PMID: 29945992
Targeting Endoglin-Expressing Regulatory T Cells in the Tumor Microenvironment Enhances the Effect of PD1 Checkpoint Inhibitor Immunotherapy.
Schoonderwoerd MJA, Koops MFM, Angela RA, Koolmoes B, Toitou M, Paauwe M, Barnhoorn MC, Liu Y, Sier CFM, Hardwick JCH, Nixon AB, Theuer CP, Fransen MF, Hawinkels LJAC. Schoonderwoerd MJA, et al. Clin Cancer Res. 2020 Jul 15;26(14):3831-3842. doi: 10.1158/1078-0432.CCR-19-2889. Epub 2020 Apr 24. Clin Cancer Res. 2020. PMID: 32332012
162 results