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Enhanced antigen cross-presentation in human colorectal cancer-associated fibroblasts through upregulation of the lysosomal protease cathepsin S.
Harryvan TJ, Visser M, de Bruin L, Plug L, Griffioen L, Mulder A, van Veelen PA, van der Heden van Noort GJ, Jongsma ML, Meeuwsen MH, Wiertz EJ, Santegoets SJ, Hardwick JC, Van Hall T, Neefjes J, Van der Burg SH, Hawinkels LJ, Verdegaal EM. Harryvan TJ, et al. Among authors: hawinkels lj. J Immunother Cancer. 2022 Mar;10(3):e003591. doi: 10.1136/jitc-2021-003591. J Immunother Cancer. 2022. PMID: 35264435 Free PMC article.
The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC.
Voorneveld PW, Kodach LL, Jacobs RJ, van Noesel CJ, Peppelenbosch MP, Korkmaz KS, Molendijk I, Dekker E, Morreau H, van Pelt GW, Tollenaar RA, Mesker W, Hawinkels LJ, Paauwe M, Verspaget HW, Geraets DT, Hommes DW, Offerhaus GJ, van den Brink GR, Ten Dijke P, Hardwick JC. Voorneveld PW, et al. Among authors: hawinkels lj. Br J Cancer. 2015 Jan 6;112(1):122-30. doi: 10.1038/bjc.2014.560. Epub 2014 Nov 13. Br J Cancer. 2015. PMID: 25393365 Free PMC article.
Putting the Wnt up colon cancer.
Hawinkels LJ, Hardwick JC. Hawinkels LJ, et al. Gut. 2017 Jun;66(6):983-984. doi: 10.1136/gutjnl-2016-312584. Epub 2016 Nov 10. Gut. 2017. PMID: 28501817 No abstract available.
Endoglin Expression on Cancer-Associated Fibroblasts Regulates Invasion and Stimulates Colorectal Cancer Metastasis.
Paauwe M, Schoonderwoerd MJA, Helderman RFCP, Harryvan TJ, Groenewoud A, van Pelt GW, Bor R, Hemmer DM, Versteeg HH, Snaar-Jagalska BE, Theuer CP, Hardwick JCH, Sier CFM, Ten Dijke P, Hawinkels LJAC. Paauwe M, et al. Clin Cancer Res. 2018 Dec 15;24(24):6331-6344. doi: 10.1158/1078-0432.CCR-18-0329. Epub 2018 Jun 26. Clin Cancer Res. 2018. PMID: 29945992
Tumor-draining lymph nodes are pivotal in PD-1/PD-L1 checkpoint therapy.
Fransen MF, Schoonderwoerd M, Knopf P, Camps MG, Hawinkels LJ, Kneilling M, van Hall T, Ossendorp F. Fransen MF, et al. Among authors: hawinkels lj. JCI Insight. 2018 Dec 6;3(23):e124507. doi: 10.1172/jci.insight.124507. JCI Insight. 2018. PMID: 30518694 Free PMC article.
92 results