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Mature iPSC-derived astrocytes of an ALS/FTD patient carrying the TDP43A90V mutation display a mild reactive state and release polyP toxic to motoneurons.
Front Cell Dev Biol. 2023 Jul 28;11:1226604. doi: 10.3389/fcell.2023.1226604. eCollection 2023.
Front Cell Dev Biol. 2023.
PMID: 37645251
Free PMC article.
Influence of the N-representability conditions on the variational determination of two-electron reduced density matrices for ground and excited N-electron states in the doubly occupied configuration interaction space.
Corvalan DA, Oña OB, Alcoba DR, Torre A, Lain L, Massaccesi GE.
Corvalan DA, et al.
J Chem Phys. 2022 Nov 28;157(20):204103. doi: 10.1063/5.0116222.
J Chem Phys. 2022.
PMID: 36456222
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Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons.
Arredondo C, Cefaliello C, Dyrda A, Jury N, Martinez P, Díaz I, Amaro A, Tran H, Morales D, Pertusa M, Stoica L, Fritz E, Corvalán D, Abarzúa S, Méndez-Ruette M, Fernández P, Rojas F, Kumar MS, Aguilar R, Almeida S, Weiss A, Bustos FJ, González-Nilo F, Otero C, Tevy MF, Bosco DA, Sáez JC, Kähne T, Gao FB, Berry JD, Nicholson K, Sena-Esteves M, Madrid R, Varela D, Montecino M, Brown RH, van Zundert B.
Arredondo C, et al. Among authors: corvalan d.
Neuron. 2022 May 18;110(10):1656-1670.e12. doi: 10.1016/j.neuron.2022.02.010. Epub 2022 Mar 10.
Neuron. 2022.
PMID: 35276083
Free PMC article.
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