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Excessive release of inorganic polyphosphate by ALS/FTD astrocytes causes non-cell-autonomous toxicity to motoneurons.
Arredondo C, Cefaliello C, Dyrda A, Jury N, Martinez P, Díaz I, Amaro A, Tran H, Morales D, Pertusa M, Stoica L, Fritz E, Corvalán D, Abarzúa S, Méndez-Ruette M, Fernández P, Rojas F, Kumar MS, Aguilar R, Almeida S, Weiss A, Bustos FJ, González-Nilo F, Otero C, Tevy MF, Bosco DA, Sáez JC, Kähne T, Gao FB, Berry JD, Nicholson K, Sena-Esteves M, Madrid R, Varela D, Montecino M, Brown RH, van Zundert B. Arredondo C, et al. Among authors: saez jc. Neuron. 2022 May 18;110(10):1656-1670.e12. doi: 10.1016/j.neuron.2022.02.010. Epub 2022 Mar 10. Neuron. 2022. PMID: 35276083 Free PMC article.
A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII.
López X, Palacios-Prado N, Güiza J, Escamilla R, Fernández P, Vega JL, Rojas M, Marquez-Miranda V, Chamorro E, Cárdenas AM, Maldifassi MC, Martínez AD, Duarte Y, González-Nilo FD, Sáez JC. López X, et al. Among authors: saez jc. Proc Natl Acad Sci U S A. 2021 Aug 10;118(32):e2108967118. doi: 10.1073/pnas.2108967118. Proc Natl Acad Sci U S A. 2021. PMID: 34301850 Free PMC article.
Unnexins: Homologs of innexin proteins in Trypanosomatidae parasites.
Güiza J, García A, Arriagada J, Gutiérrez C, González J, Márquez-Miranda V, Alegría-Arcos M, Duarte Y, Rojas M, González-Nilo F, Sáez JC, Vega JL. Güiza J, et al. Among authors: saez jc. J Cell Physiol. 2022 Feb;237(2):1547-1560. doi: 10.1002/jcp.30626. Epub 2021 Nov 15. J Cell Physiol. 2022. PMID: 34779505
Endogenous pannexin1 channels form functional intercellular cell-cell channels with characteristic voltage-dependent properties.
Palacios-Prado N, Soto PA, López X, Choi EJ, Marquez-Miranda V, Rojas M, Duarte Y, Lee J, González-Nilo FD, Sáez JC. Palacios-Prado N, et al. Among authors: saez jc. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2202104119. doi: 10.1073/pnas.2202104119. Epub 2022 Apr 29. Proc Natl Acad Sci U S A. 2022. PMID: 35486697 Free PMC article.
233 results