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Precision analysis of mutant U2AF1 activity reveals deployment of stress granules in myeloid malignancies.
Biancon G, Joshi P, Zimmer JT, Hunck T, Gao Y, Lessard MD, Courchaine E, Barentine AES, Machyna M, Botti V, Qin A, Gbyli R, Patel A, Song Y, Kiefer L, Viero G, Neuenkirchen N, Lin H, Bewersdorf J, Simon MD, Neugebauer KM, Tebaldi T, Halene S. Biancon G, et al. Among authors: gao y. Mol Cell. 2022 Mar 17;82(6):1107-1122.e7. doi: 10.1016/j.molcel.2022.02.025. Mol Cell. 2022. PMID: 35303483 Free PMC article.
In vivo anti-tumor effect of PARP inhibition in IDH1/2 mutant MDS/AML resistant to targeted inhibitors of mutant IDH1/2.
Gbyli R, Song Y, Liu W, Gao Y, Biancon G, Chandhok NS, Wang X, Fu X, Patel A, Sundaram R, Tebaldi T, Mamillapalli P, Zeidan AM, Flavell RA, Prebet T, Bindra RS, Halene S. Gbyli R, et al. Among authors: gao y. Leukemia. 2022 May;36(5):1313-1323. doi: 10.1038/s41375-022-01536-x. Epub 2022 Mar 10. Leukemia. 2022. PMID: 35273342 Free PMC article.
Combined liver-cytokine humanization comes to the rescue of circulating human red blood cells.
Song Y, Shan L, Gbyli R, Liu W, Strowig T, Patel A, Fu X, Wang X, Xu ML, Gao Y, Qin A, Bruscia EM, Tebaldi T, Biancon G, Mamillapalli P, Urbonas D, Eynon E, Gonzalez DG, Chen J, Krause DS, Alderman J, Halene S, Flavell RA. Song Y, et al. Among authors: gao y. Science. 2021 Mar 5;371(6533):1019-1025. doi: 10.1126/science.abe2485. Science. 2021. PMID: 33674488 Free PMC article.
m6A Modification Prevents Formation of Endogenous Double-Stranded RNAs and Deleterious Innate Immune Responses during Hematopoietic Development.
Gao Y, Vasic R, Song Y, Teng R, Liu C, Gbyli R, Biancon G, Nelakanti R, Lobben K, Kudo E, Liu W, Ardasheva A, Fu X, Wang X, Joshi P, Lee V, Dura B, Viero G, Iwasaki A, Fan R, Xiao A, Flavell RA, Li HB, Tebaldi T, Halene S. Gao Y, et al. Immunity. 2020 Jun 16;52(6):1007-1021.e8. doi: 10.1016/j.immuni.2020.05.003. Epub 2020 Jun 3. Immunity. 2020. PMID: 32497523 Free PMC article.
A highly efficient and faithful MDS patient-derived xenotransplantation model for pre-clinical studies.
Song Y, Rongvaux A, Taylor A, Jiang T, Tebaldi T, Balasubramanian K, Bagale A, Terzi YK, Gbyli R, Wang X, Fu X, Gao Y, Zhao J, Podoltsev N, Xu M, Neparidze N, Wong E, Torres R, Bruscia EM, Kluger Y, Manz MG, Flavell RA, Halene S. Song Y, et al. Among authors: gao y. Nat Commun. 2019 Jan 21;10(1):366. doi: 10.1038/s41467-018-08166-x. Nat Commun. 2019. PMID: 30664659 Free PMC article.
RNA m6A demethylase ALKBH5 regulates the development of γδ T cells.
Ding C, Xu H, Yu Z, Roulis M, Qu R, Zhou J, Oh J, Crawford J, Gao Y, Jackson R, Sefik E, Li S, Wei Z, Skadow M, Yin Z, Ouyang X, Wang L, Zou Q, Su B, Hu W, Flavell RA, Li HB. Ding C, et al. Among authors: gao y. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2203318119. doi: 10.1073/pnas.2203318119. Epub 2022 Aug 8. Proc Natl Acad Sci U S A. 2022. PMID: 35939687 Free PMC article.
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