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Stromal cues regulate the pancreatic cancer epigenome and metabolome.
Sherman MH, Yu RT, Tseng TW, Sousa CM, Liu S, Truitt ML, He N, Ding N, Liddle C, Atkins AR, Leblanc M, Collisson EA, Asara JM, Kimmelman AC, Downes M, Evans RM. Sherman MH, et al. Among authors: kimmelman ac. Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1129-1134. doi: 10.1073/pnas.1620164114. Epub 2017 Jan 17. Proc Natl Acad Sci U S A. 2017. PMID: 28096419 Free PMC article.
Metabolic Interactions in the Tumor Microenvironment.
Lyssiotis CA, Kimmelman AC. Lyssiotis CA, et al. Among authors: kimmelman ac. Trends Cell Biol. 2017 Nov;27(11):863-875. doi: 10.1016/j.tcb.2017.06.003. Epub 2017 Jul 19. Trends Cell Biol. 2017. PMID: 28734735 Free PMC article. Review.
Glutamine metabolism via glutaminase 1 in autosomal-dominant polycystic kidney disease.
Soomro I, Sun Y, Li Z, Diggs L, Hatzivassiliou G, Thomas AG, Rais R, Parker SJ, Slusher BS, Kimmelman AC, Somlo S, Skolnik EY. Soomro I, et al. Among authors: kimmelman ac. Nephrol Dial Transplant. 2018 Aug 1;33(8):1343-1353. doi: 10.1093/ndt/gfx349. Nephrol Dial Transplant. 2018. PMID: 29420817 Free PMC article.
Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic Cancer.
Parker SJ, Amendola CR, Hollinshead KER, Yu Q, Yamamoto K, Encarnación-Rosado J, Rose RE, LaRue MM, Sohn ASW, Biancur DE, Paulo JA, Gygi SP, Jones DR, Wang H, Philips MR, Bar-Sagi D, Mancias JD, Kimmelman AC. Parker SJ, et al. Among authors: kimmelman ac. Cancer Discov. 2020 Jul;10(7):1018-1037. doi: 10.1158/2159-8290.CD-19-0959. Epub 2020 Apr 27. Cancer Discov. 2020. PMID: 32341021 Free PMC article.
Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I.
Yamamoto K, Venida A, Yano J, Biancur DE, Kakiuchi M, Gupta S, Sohn ASW, Mukhopadhyay S, Lin EY, Parker SJ, Banh RS, Paulo JA, Wen KW, Debnath J, Kim GE, Mancias JD, Fearon DT, Perera RM, Kimmelman AC. Yamamoto K, et al. Among authors: kimmelman ac. Nature. 2020 May;581(7806):100-105. doi: 10.1038/s41586-020-2229-5. Epub 2020 Apr 22. Nature. 2020. PMID: 32376951 Free PMC article.
Harnessing metabolic dependencies in pancreatic cancers.
Encarnación-Rosado J, Kimmelman AC. Encarnación-Rosado J, et al. Among authors: kimmelman ac. Nat Rev Gastroenterol Hepatol. 2021 Jul;18(7):482-492. doi: 10.1038/s41575-021-00431-7. Epub 2021 Mar 19. Nat Rev Gastroenterol Hepatol. 2021. PMID: 33742165 Free PMC article. Review.
117 results