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Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183.
de Vries LE, Jansen PAM, Barcelo C, Munro J, Verhoef JMJ, Pasaje CFA, Rubiano K, Striepen J, Abla N, Berning L, Bolscher JM, Demarta-Gatsi C, Henderson RWM, Huijs T, Koolen KMJ, Tumwebaze PK, Yeo T, Aguiar ACC, Angulo-Barturen I, Churchyard A, Baum J, Fernández BC, Fuchs A, Gamo FJ, Guido RVC, Jiménez-Diaz MB, Pereira DB, Rochford R, Roesch C, Sanz LM, Trevitt G, Witkowski B, Wittlin S, Cooper RA, Rosenthal PJ, Sauerwein RW, Schalkwijk J, Hermkens PHH, Bonnert RV, Campo B, Fidock DA, Llinás M, Niles JC, Kooij TWA, Dechering KJ. de Vries LE, et al. Among authors: henderson rwm. Nat Commun. 2022 Apr 20;13(1):2158. doi: 10.1038/s41467-022-29688-5. Nat Commun. 2022. PMID: 35444200 Free PMC article.
Replenishing the malaria drug discovery pipeline: Screening and hit evaluation of the MMV Hit Generation Library 1 (HGL1) against asexual blood stage Plasmodium falciparum, using a nano luciferase reporter read-out.
Dechering KJ, Timmerman M, Rensen K, Koolen KMJ, Honarnejad S, Vos MW, Huijs T, Henderson RWM, Chenu E, Laleu B, Montefiore BC, Segall MD, Mills JEJ, Guantai EM, Duffy J, Duffey M. Dechering KJ, et al. Among authors: henderson rwm. SLAS Discov. 2022 Sep;27(6):337-348. doi: 10.1016/j.slasd.2022.07.002. Epub 2022 Jul 21. SLAS Discov. 2022. PMID: 35872229 Free article.
The Nitrobenzoxadiazole Derivative NBDHEX Behaves as Plasmodium falciparum Gametocyte Selective Inhibitor with Malaria Parasite Transmission Blocking Activity.
Siciliano G, Di Paolo V, Rotili D, Migale R, Pedini F, Casella M, Camerini S, Dalzoppo D, Henderson R, Huijs T, Dechering KJ, Mai A, Caccuri AM, Lalle M, Quintieri L, Alano P. Siciliano G, et al. Pharmaceuticals (Basel). 2022 Jan 29;15(2):168. doi: 10.3390/ph15020168. Pharmaceuticals (Basel). 2022. PMID: 35215282 Free PMC article.