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Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function.
Meisgen S, Hedlund M, Ambrosi A, Folkersen L, Ottosson V, Forsberg D, Thorlacius GE, Biavati L, Strandberg L, Mofors J, Ramskold D, Ruhrmann S, Meneghel L, Nyberg W, Espinosa A, Hamilton RM, Franco-Cereceda A, Hamsten A, Olsson T, Greene L, Eriksson P, Gemzell-Danielsson K, Salomonsson S, Kuchroo VK, Herlenius E, Kockum I, Sonesson SE, Wahren-Herlenius M. Meisgen S, et al. Among authors: ambrosi a. Ann Rheum Dis. 2022 Aug;81(8):1151-1161. doi: 10.1136/annrheumdis-2021-221714. Epub 2022 Apr 25. Ann Rheum Dis. 2022. PMID: 35470161 Free PMC article.
Maternal MHC regulates generation of pathogenic antibodies and fetal MHC-encoded genes determine susceptibility in congenital heart block.
Strandberg LS, Ambrosi A, Jagodic M, Dzikaite V, Janson P, Khademi M, Salomonsson S, Ottosson L, Klauninger R, Adén U, Sonesson SE, Sunnerhagen M, de Graaf KL, Kuchroo VK, Achour A, Winqvist O, Olsson T, Wahren-Herlenius M. Strandberg LS, et al. Among authors: ambrosi a. J Immunol. 2010 Sep 15;185(6):3574-82. doi: 10.4049/jimmunol.1001396. Epub 2010 Aug 9. J Immunol. 2010. PMID: 20696861
Development of heart block in children of SSA/SSB-autoantibody-positive women is associated with maternal age and displays a season-of-birth pattern.
Ambrosi A, Salomonsson S, Eliasson H, Zeffer E, Skog A, Dzikaite V, Bergman G, Fernlund E, Tingström J, Theander E, Rydberg A, Skogh T, Öhman A, Lundström U, Mellander M, Winqvist O, Fored M, Ekbom A, Alfredsson L, Källberg H, Olsson T, Gadler F, Jonzon A, Kockum I, Sonesson SE, Wahren-Herlenius M. Ambrosi A, et al. Ann Rheum Dis. 2012 Mar;71(3):334-40. doi: 10.1136/annrheumdis-2011-200207. Epub 2011 Sep 27. Ann Rheum Dis. 2012. PMID: 21953338
Molecular mechanisms of congenital heart block.
Ambrosi A, Sonesson SE, Wahren-Herlenius M. Ambrosi A, et al. Exp Cell Res. 2014 Jul 1;325(1):2-9. doi: 10.1016/j.yexcr.2014.01.003. Epub 2014 Jan 13. Exp Cell Res. 2014. PMID: 24434353 Review.
402 results