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Cystine uptake inhibition potentiates front-line therapies in acute myeloid leukemia.
Pardieu B, Pasanisi J, Ling F, Dal Bello R, Penneroux J, Su A, Joudinaud R, Chat L, Wu HC, Duchmann M, Sodaro G, Chauvel C, Castelli FA, Vasseur L, Pacchiardi K, Belloucif Y, Laiguillon MC, Meduri E, Vaganay C, Alexe G, Berrou J, Benaksas C, Forget A, Braun T, Gardin C, Raffoux E, Clappier E, Adès L, de Thé H, Fenaille F, Huntly BJ, Stegmaier K, Dombret H, Fenouille N, Lobry C, Puissant A, Itzykson R. Pardieu B, et al. Among authors: wu hc. Leukemia. 2022 Jun;36(6):1585-1595. doi: 10.1038/s41375-022-01573-6. Epub 2022 Apr 26. Leukemia. 2022. PMID: 35474100
Dactinomycin induces complete remission associated with nucleolar stress response in relapsed/refractory NPM1-mutated AML.
Gionfriddo I, Brunetti L, Mezzasoma F, Milano F, Cardinali V, Ranieri R, Venanzi A, Pierangeli S, Vetro C, Spinozzi G, Dorillo E, Wu HC, Berthier C, Ciurnelli R, Griffin MJ, Jennings CE, Tiacci E, Sportoletti P, Falzetti F, de Thé H, Veal GJ, Martelli MP, Falini B. Gionfriddo I, et al. Among authors: wu hc. Leukemia. 2021 Sep;35(9):2552-2562. doi: 10.1038/s41375-021-01192-7. Epub 2021 Mar 2. Leukemia. 2021. PMID: 33654209 Free PMC article. Clinical Trial.
A Pin1/PML/P53 axis activated by retinoic acid in NPM-1c acute myeloid leukemia.
Hleihel R, El Hajj H, Wu HC, Berthier C, Zhu HH, Massoud R, Chakhachiro Z, El Sabban M, De The H, Bazarbachi A. Hleihel R, et al. Among authors: wu hc. Haematologica. 2021 Dec 1;106(12):3090-3099. doi: 10.3324/haematol.2020.274878. Haematologica. 2021. PMID: 34047175 Free PMC article.
Actinomycin D Targets NPM1c-Primed Mitochondria to Restore PML-Driven Senescence in AML Therapy.
Wu HC, Rérolle D, Berthier C, Hleihel R, Sakamoto T, Quentin S, Benhenda S, Morganti C, Wu C, Conte L, Rimsky S, Sebert M, Clappier E, Souquere S, Gachet S, Soulier J, Durand S, Trowbridge JJ, Bénit P, Rustin P, El Hajj H, Raffoux E, Ades L, Itzykson R, Dombret H, Fenaux P, Espeli O, Kroemer G, Brunetti L, Mak TW, Lallemand-Breitenbach V, Bazarbachi A, Falini B, Ito K, Martelli MP, de Thé H. Wu HC, et al. Among authors: wu c. Cancer Discov. 2021 Dec 1;11(12):3198-3213. doi: 10.1158/2159-8290.CD-21-0177. Cancer Discov. 2021. PMID: 34301789 Free PMC article.
Biological Effects of BET Inhibition by OTX015 (MK-8628) and JQ1 in NPM1-Mutated (NPM1c) Acute Myeloid Leukemia (AML).
Djamai H, Berrou J, Dupont M, Coudé MM, Delord M, Clappier E, Marceau-Renaut A, Kaci A, Raffoux E, Itzykson R, Berthier C, Wu HC, Hleihel R, Bazarbachi A, de Thé H, Baruchel A, Gardin C, Dombret H, Braun T. Djamai H, et al. Among authors: wu hc. Biomedicines. 2021 Nov 17;9(11):1704. doi: 10.3390/biomedicines9111704. Biomedicines. 2021. PMID: 34829934 Free PMC article.
PML nuclear bodies, membrane-less domains acting as ROS sensors?
Niwa-Kawakita M, Wu HC, Thé H, Lallemand-Breitenbach V. Niwa-Kawakita M, et al. Among authors: wu hc. Semin Cell Dev Biol. 2018 Aug;80:29-34. doi: 10.1016/j.semcdb.2017.11.007. Epub 2017 Nov 20. Semin Cell Dev Biol. 2018. PMID: 29157919 Review.
1,541 results