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Dysregulation of macrophage PEPD in obesity determines adipose tissue fibro-inflammation and insulin resistance.
Pellegrinelli V, Rodriguez-Cuenca S, Rouault C, Figueroa-Juarez E, Schilbert H, Virtue S, Moreno-Navarrete JM, Bidault G, Vázquez-Borrego MC, Dias AR, Pucker B, Dale M, Campbell M, Carobbio S, Lin YH, Vacca M, Aron-Wisnewsky J, Mora S, Masiero MM, Emmanouilidou A, Mukhopadhyay S, Dougan G, den Hoed M, Loos RJF, Fernández-Real JM, Chiarugi D, Clément K, Vidal-Puig A. Pellegrinelli V, et al. Among authors: virtue s. Nat Metab. 2022 Apr;4(4):476-494. doi: 10.1038/s42255-022-00561-5. Epub 2022 Apr 25. Nat Metab. 2022. PMID: 35478031 Free article.
PPAR gamma 2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism.
Medina-Gomez G, Gray SL, Yetukuri L, Shimomura K, Virtue S, Campbell M, Curtis RK, Jimenez-Linan M, Blount M, Yeo GS, Lopez M, Seppänen-Laakso T, Ashcroft FM, Oresic M, Vidal-Puig A. Medina-Gomez G, et al. Among authors: virtue s. PLoS Genet. 2007 Apr 27;3(4):e64. doi: 10.1371/journal.pgen.0030064. PLoS Genet. 2007. PMID: 17465682 Free PMC article.
Orexin expression is regulated by alpha-melanocyte-stimulating hormone.
López M, Lage R, Tung YC, Challis BG, Varela L, Virtue S, O'Rahilly S, Vidal-Puig A, Diéguez C, Coll AP. López M, et al. Among authors: virtue s. J Neuroendocrinol. 2007 Sep;19(9):703-7. doi: 10.1111/j.1365-2826.2007.01577.x. J Neuroendocrinol. 2007. PMID: 17680885 Free PMC article.
It's not how fat you are, it's what you do with it that counts.
Virtue S, Vidal-Puig A. Virtue S, et al. PLoS Biol. 2008 Sep 23;6(9):e237. doi: 10.1371/journal.pbio.0060237. PLoS Biol. 2008. PMID: 18816166 Free PMC article.
Mechanisms underlying obesity-related metabolic disorders are poorly understood. Samuel Virtue and Antonio Vidal-Puig explore the evidence for an emerging hypothesis that attributes metabolic complications not to obesity per se, but to an individual's capacity for a …
Mechanisms underlying obesity-related metabolic disorders are poorly understood. Samuel Virtue and Antonio Vidal-Puig explore the evi …
Secreted frizzled-related protein 1 regulates adipose tissue expansion and is dysregulated in severe obesity.
Lagathu C, Christodoulides C, Tan CY, Virtue S, Laudes M, Campbell M, Ishikawa K, Ortega F, Tinahones FJ, Fernández-Real JM, Orešič M, Sethi JK, Vidal-Puig A. Lagathu C, et al. Among authors: virtue s. Int J Obes (Lond). 2010 Dec;34(12):1695-705. doi: 10.1038/ijo.2010.107. Epub 2010 Jun 1. Int J Obes (Lond). 2010. PMID: 20514047 Free PMC article.
Association of lipidome remodeling in the adipocyte membrane with acquired obesity in humans.
Pietiläinen KH, Róg T, Seppänen-Laakso T, Virtue S, Gopalacharyulu P, Tang J, Rodriguez-Cuenca S, Maciejewski A, Naukkarinen J, Ruskeepää AL, Niemelä PS, Yetukuri L, Tan CY, Velagapudi V, Castillo S, Nygren H, Hyötyläinen T, Rissanen A, Kaprio J, Yki-Järvinen H, Vattulainen I, Vidal-Puig A, Orešič M. Pietiläinen KH, et al. Among authors: virtue s. PLoS Biol. 2011 Jun;9(6):e1000623. doi: 10.1371/journal.pbio.1000623. Epub 2011 Jun 7. PLoS Biol. 2011. PMID: 21666801 Free PMC article.
120 results