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Stepwise-edited, human melanoma models reveal mutations' effect on tumor and microenvironment.
Hodis E, Torlai Triglia E, Kwon JYH, Biancalani T, Zakka LR, Parkar S, Hütter JC, Buffoni L, Delorey TM, Phillips D, Dionne D, Nguyen LT, Schapiro D, Maliga Z, Jacobson CA, Hendel A, Rozenblatt-Rosen O, Mihm MC Jr, Garraway LA, Regev A. Hodis E, et al. Among authors: hendel a. Science. 2022 Apr 29;376(6592):eabi8175. doi: 10.1126/science.abi8175. Epub 2022 Apr 29. Science. 2022. PMID: 35482859 Free PMC article.
Different hotspot p53 mutants exert distinct phenotypes and predict outcome of colorectal cancer patients.
Hassin O, Nataraj NB, Shreberk-Shaked M, Aylon Y, Yaeger R, Fontemaggi G, Mukherjee S, Maddalena M, Avioz A, Iancu O, Mallel G, Gershoni A, Grosheva I, Feldmesser E, Ben-Dor S, Golani O, Hendel A, Blandino G, Kelsen D, Yarden Y, Oren M. Hassin O, et al. Among authors: hendel a. Nat Commun. 2022 May 19;13(1):2800. doi: 10.1038/s41467-022-30481-7. Nat Commun. 2022. PMID: 35589715 Free PMC article.
CRISPR-based gene editing enables FOXP3 gene repair in IPEX patient cells.
Goodwin M, Lee E, Lakshmanan U, Shipp S, Froessl L, Barzaghi F, Passerini L, Narula M, Sheikali A, Lee CM, Bao G, Bauer CS, Miller HK, Garcia-Lloret M, Butte MJ, Bertaina A, Shah A, Pavel-Dinu M, Hendel A, Porteus M, Roncarolo MG, Bacchetta R. Goodwin M, et al. Among authors: hendel a. Sci Adv. 2020 May 6;6(19):eaaz0571. doi: 10.1126/sciadv.aaz0571. eCollection 2020 May. Sci Adv. 2020. PMID: 32494707 Free PMC article.
Inherited SLP76 deficiency in humans causes severe combined immunodeficiency, neutrophil and platelet defects.
Lev A, Lee YN, Sun G, Hallumi E, Simon AJ, Zrihen KS, Levy S, Beit Halevi T, Papazian M, Shwartz N, Somekh I, Levy-Mendelovich S, Wolach B, Gavrieli R, Vernitsky H, Barel O, Javasky E, Stauber T, Ma CA, Zhang Y, Amariglio N, Rechavi G, Hendel A, Yablonski D, Milner JD, Somech R. Lev A, et al. Among authors: hendel a. J Exp Med. 2021 Mar 1;218(3):e20201062. doi: 10.1084/jem.20201062. J Exp Med. 2021. PMID: 33231617 Free PMC article.
Microfluidic tool for rapid functional characterization of CRISPR complexes.
Peleg-Chen D, Shuvali G, Brio L, Ifrach A, Iancu O, Barbiro-Michaely E, Hendel A, Gerber D. Peleg-Chen D, et al. Among authors: hendel a. N Biotechnol. 2022 May 25;68:1-8. doi: 10.1016/j.nbt.2022.01.003. Epub 2022 Jan 10. N Biotechnol. 2022. PMID: 35026470 Free PMC article.
Nicotinamide-Expanded Allogeneic Natural Killer Cells with CD38 Deletion, Expressing an Enhanced CD38 Chimeric Antigen Receptor, Target Multiple Myeloma Cells.
Edri A, Ben-Haim N, Hailu A, Brycman N, Berhani-Zipori O, Rifman J, Cohen S, Yackoubov D, Rosenberg M, Simantov R, Teru H, Kurata K, Anderson KC, Hendel A, Pato A, Geffen Y. Edri A, et al. Among authors: hendel a. Int J Mol Sci. 2023 Dec 7;24(24):17231. doi: 10.3390/ijms242417231. Int J Mol Sci. 2023. PMID: 38139060 Free PMC article.
55 results