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Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control.
Gideon HP, Hughes TK, Tzouanas CN, Wadsworth MH 2nd, Tu AA, Gierahn TM, Peters JM, Hopkins FF, Wei JR, Kummerlowe C, Grant NL, Nargan K, Phuah JY, Borish HJ, Maiello P, White AG, Winchell CG, Nyquist SK, Ganchua SKC, Myers A, Patel KV, Ameel CL, Cochran CT, Ibrahim S, Tomko JA, Frye LJ, Rosenberg JM, Shih A, Chao M, Klein E, Scanga CA, Ordovas-Montanes J, Berger B, Mattila JT, Madansein R, Love JC, Lin PL, Leslie A, Behar SM, Bryson B, Flynn JL, Fortune SM, Shalek AK. Gideon HP, et al. Immunity. 2022 May 10;55(5):827-846.e10. doi: 10.1016/j.immuni.2022.04.004. Epub 2022 Apr 27. Immunity. 2022. PMID: 35483355 Free PMC article.
Latent tuberculosis: what the host "sees"?
Gideon HP, Flynn JL. Gideon HP, et al. Immunol Res. 2011 Aug;50(2-3):202-12. doi: 10.1007/s12026-011-8229-7. Immunol Res. 2011. PMID: 21717066 Free PMC article. Review.
The multistage vaccine H56 boosts the effects of BCG to protect cynomolgus macaques against active tuberculosis and reactivation of latent Mycobacterium tuberculosis infection.
Lin PL, Dietrich J, Tan E, Abalos RM, Burgos J, Bigbee C, Bigbee M, Milk L, Gideon HP, Rodgers M, Cochran C, Guinn KM, Sherman DR, Klein E, Janssen C, Flynn JL, Andersen P. Lin PL, et al. Among authors: gideon hp. J Clin Invest. 2012 Jan;122(1):303-14. doi: 10.1172/JCI46252. Epub 2011 Dec 1. J Clin Invest. 2012. PMID: 22133873 Free PMC article.
Computational modeling predicts IL-10 control of lesion sterilization by balancing early host immunity-mediated antimicrobial responses with caseation during mycobacterium tuberculosis infection.
Cilfone NA, Ford CB, Marino S, Mattila JT, Gideon HP, Flynn JL, Kirschner DE, Linderman JJ. Cilfone NA, et al. Among authors: gideon hp. J Immunol. 2015 Jan 15;194(2):664-77. doi: 10.4049/jimmunol.1400734. Epub 2014 Dec 15. J Immunol. 2015. PMID: 25512604 Free PMC article.
Variability in tuberculosis granuloma T cell responses exists, but a balance of pro- and anti-inflammatory cytokines is associated with sterilization.
Gideon HP, Phuah J, Myers AJ, Bryson BD, Rodgers MA, Coleman MT, Maiello P, Rutledge T, Marino S, Fortune SM, Kirschner DE, Lin PL, Flynn JL. Gideon HP, et al. PLoS Pathog. 2015 Jan 22;11(1):e1004603. doi: 10.1371/journal.ppat.1004603. eCollection 2015 Jan. PLoS Pathog. 2015. PMID: 25611466 Free PMC article.
PET CT Identifies Reactivation Risk in Cynomolgus Macaques with Latent M. tuberculosis.
Lin PL, Maiello P, Gideon HP, Coleman MT, Cadena AM, Rodgers MA, Gregg R, O'Malley M, Tomko J, Fillmore D, Frye LJ, Rutledge T, DiFazio RM, Janssen C, Klein E, Andersen PL, Fortune SM, Flynn JL. Lin PL, et al. Among authors: gideon hp. PLoS Pathog. 2016 Jul 5;12(7):e1005739. doi: 10.1371/journal.ppat.1005739. eCollection 2016 Jul. PLoS Pathog. 2016. PMID: 27379816 Free PMC article.
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