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Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation.
Yshii L, Pasciuto E, Bielefeld P, Mascali L, Lemaitre P, Marino M, Dooley J, Kouser L, Verschoren S, Lagou V, Kemps H, Gervois P, de Boer A, Burton OT, Wahis J, Verhaert J, Tareen SHK, Roca CP, Singh K, Whyte CE, Kerstens A, Callaerts-Vegh Z, Poovathingal S, Prezzemolo T, Wierda K, Dashwood A, Xie J, Van Wonterghem E, Creemers E, Aloulou M, Gsell W, Abiega O, Munck S, Vandenbroucke RE, Bronckaers A, Lemmens R, De Strooper B, Van Den Bosch L, Himmelreich U, Fitzsimons CP, Holt MG, Liston A. Yshii L, et al. Among authors: de strooper b, de boer a. Nat Immunol. 2022 Jun;23(6):878-891. doi: 10.1038/s41590-022-01208-z. Epub 2022 May 26. Nat Immunol. 2022. PMID: 35618831 Free PMC article.
The thymic epithelial microRNA network elevates the threshold for infection-associated thymic involution via miR-29a mediated suppression of the IFN-α receptor.
Papadopoulou AS, Dooley J, Linterman MA, Pierson W, Ucar O, Kyewski B, Zuklys S, Hollander GA, Matthys P, Gray DH, De Strooper B, Liston A. Papadopoulou AS, et al. Among authors: de strooper b. Nat Immunol. 2011 Dec 18;13(2):181-7. doi: 10.1038/ni.2193. Nat Immunol. 2011. PMID: 22179202 Free PMC article.
Epigenetically regulated microRNAs in Alzheimer's disease.
Van den Hove DL, Kompotis K, Lardenoije R, Kenis G, Mill J, Steinbusch HW, Lesch KP, Fitzsimons CP, De Strooper B, Rutten BP. Van den Hove DL, et al. Among authors: de strooper b. Neurobiol Aging. 2014 Apr;35(4):731-45. doi: 10.1016/j.neurobiolaging.2013.10.082. Epub 2013 Oct 18. Neurobiol Aging. 2014. PMID: 24238656 Review.
Deficiency of the miR-29a/b-1 cluster leads to ataxic features and cerebellar alterations in mice.
Papadopoulou AS, Serneels L, Achsel T, Mandemakers W, Callaerts-Vegh Z, Dooley J, Lau P, Ayoubi T, Radaelli E, Spinazzi M, Neumann M, Hébert SS, Silahtaroglu A, Liston A, D'Hooge R, Glatzel M, De Strooper B. Papadopoulou AS, et al. Among authors: de strooper b. Neurobiol Dis. 2015 Jan;73:275-88. doi: 10.1016/j.nbd.2014.10.006. Epub 2014 Oct 12. Neurobiol Dis. 2015. PMID: 25315682
Dysregulated ADAM10-Mediated Processing of APP during a Critical Time Window Leads to Synaptic Deficits in Fragile X Syndrome.
Pasciuto E, Ahmed T, Wahle T, Gardoni F, D'Andrea L, Pacini L, Jacquemont S, Tassone F, Balschun D, Dotti CG, Callaerts-Vegh Z, D'Hooge R, Müller UC, Di Luca M, De Strooper B, Bagni C. Pasciuto E, et al. Among authors: de strooper b. Neuron. 2015 Jul 15;87(2):382-98. doi: 10.1016/j.neuron.2015.06.032. Neuron. 2015. PMID: 26182420 Free article.
396 results