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Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-resident regulatory T cell numbers and protects against pathological neuroinflammation.
Yshii L, Pasciuto E, Bielefeld P, Mascali L, Lemaitre P, Marino M, Dooley J, Kouser L, Verschoren S, Lagou V, Kemps H, Gervois P, de Boer A, Burton OT, Wahis J, Verhaert J, Tareen SHK, Roca CP, Singh K, Whyte CE, Kerstens A, Callaerts-Vegh Z, Poovathingal S, Prezzemolo T, Wierda K, Dashwood A, Xie J, Van Wonterghem E, Creemers E, Aloulou M, Gsell W, Abiega O, Munck S, Vandenbroucke RE, Bronckaers A, Lemmens R, De Strooper B, Van Den Bosch L, Himmelreich U, Fitzsimons CP, Holt MG, Liston A. Yshii L, et al. Among authors: van wonterghem e, van den bosch l. Nat Immunol. 2022 Jun;23(6):878-891. doi: 10.1038/s41590-022-01208-z. Epub 2022 May 26. Nat Immunol. 2022. PMID: 35618831 Free PMC article.
EPHA4 is a disease modifier of amyotrophic lateral sclerosis in animal models and in humans.
Van Hoecke A, Schoonaert L, Lemmens R, Timmers M, Staats KA, Laird AS, Peeters E, Philips T, Goris A, Dubois B, Andersen PM, Al-Chalabi A, Thijs V, Turnley AM, van Vught PW, Veldink JH, Hardiman O, Van Den Bosch L, Gonzalez-Perez P, Van Damme P, Brown RH Jr, van den Berg LH, Robberecht W. Van Hoecke A, et al. Among authors: van damme p, van den berg lh, van vught pw, van den bosch l. Nat Med. 2012 Sep;18(9):1418-22. doi: 10.1038/nm.2901. Nat Med. 2012. PMID: 22922411
Genetic ablation of phospholipase C delta 1 increases survival in SOD1(G93A) mice.
Staats KA, Van Helleputte L, Jones AR, Bento-Abreu A, Van Hoecke A, Shatunov A, Simpson CL, Lemmens R, Jaspers T, Fukami K, Nakamura Y, Brown RH Jr, Van Damme P, Liston A, Robberecht W, Al-Chalabi A, Van Den Bosch L. Staats KA, et al. Among authors: van damme p, van helleputte l, van den bosch l, van hoecke a. Neurobiol Dis. 2013 Dec;60:11-7. doi: 10.1016/j.nbd.2013.08.006. Epub 2013 Aug 19. Neurobiol Dis. 2013. PMID: 23969236
Rapamycin increases survival in ALS mice lacking mature lymphocytes.
Staats KA, Hernandez S, Schönefeldt S, Bento-Abreu A, Dooley J, Van Damme P, Liston A, Robberecht W, Van Den Bosch L. Staats KA, et al. Among authors: van damme p, van den bosch l. Mol Neurodegener. 2013 Sep 11;8:31. doi: 10.1186/1750-1326-8-31. Mol Neurodegener. 2013. PMID: 24025516 Free PMC article.
Beta-2 microglobulin is important for disease progression in a murine model for amyotrophic lateral sclerosis.
Staats KA, Schönefeldt S, Van Rillaer M, Van Hoecke A, Van Damme P, Robberecht W, Liston A, Van Den Bosch L. Staats KA, et al. Among authors: van rillaer m, van damme p, van den bosch l, van hoecke a. Front Cell Neurosci. 2013 Dec 10;7:249. doi: 10.3389/fncel.2013.00249. eCollection 2013. Front Cell Neurosci. 2013. PMID: 24368896 Free PMC article.
Transcriptional upregulation of myelin components in spontaneous myelin basic protein-deficient mice.
Staats KA, Pombal D, Schönefeldt S, Van Helleputte L, Maurin H, Dresselaers T, Govaerts K, Himmelreich U, Van Leuven F, Van Den Bosch L, Dooley J, Humblet-Baron S, Liston A. Staats KA, et al. Among authors: van leuven f, van helleputte l, van den bosch l. Brain Res. 2015 May 5;1606:125-32. doi: 10.1016/j.brainres.2015.02.021. Epub 2015 Feb 20. Brain Res. 2015. PMID: 25708149
C-kit is important for SOD1(G93A) mouse survival independent of mast cells.
Staats KA, Schönefeldt S, Van Helleputte L, Van Rillaer M, Lampi Y, Dooley J, Van Den Bosch L, Liston A. Staats KA, et al. Among authors: van rillaer m, van helleputte l, van den bosch l. Neuroscience. 2015 Aug 20;301:415-20. doi: 10.1016/j.neuroscience.2015.06.026. Epub 2015 Jun 23. Neuroscience. 2015. PMID: 26112382
317 results