Takahashi H - Search Results

1

Reversal of synapse loss in Alzheimer mouse models by targeting mGluR5 to prevent synaptic tagging by C1Q.

Spurrier J, Nicholson L, Fang XT, Stoner AJ, Toyonaga T, Holden D, Siegert TR, Laird W, Allnutt MA, Chiasseu M, Brody AH, Takahashi H, Nies SH, Pérez-Cañamás A, Sadasivam P, Lee S, Li S, Zhang L, Huang YH, Carson RE, Cai Z, Strittmatter SM. Spurrier J, et al. Among authors: takahashi h. Sci Transl Med. 2022 Jun;14(647):eabi8593. doi: 10.1126/scitranslmed.abi8593. Epub 2022 Jun 1. Sci Transl Med. 2022. PMID: 35648810 Free PMC article.

2

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein.

Um JW, Kaufman AC, Kostylev M, Heiss JK, Stagi M, Takahashi H, Kerrisk ME, Vortmeyer A, Wisniewski T, Koleske AJ, Gunther EC, Nygaard HB, Strittmatter SM. Um JW, et al. Among authors: takahashi h. Neuron. 2013 Sep 4;79(5):887-902. doi: 10.1016/j.neuron.2013.06.036. Neuron. 2013. PMID: 24012003 Free PMC article.

3

Opposing effects of progranulin deficiency on amyloid and tau pathologies via microglial TYROBP network.

Takahashi H, Klein ZA, Bhagat SM, Kaufman AC, Kostylev MA, Ikezu T, Strittmatter SM; Alzheimer’s Disease Neuroimaging Initiative. Takahashi H, et al. Acta Neuropathol. 2017 May;133(5):785-807. doi: 10.1007/s00401-017-1668-z. Epub 2017 Jan 9. Acta Neuropathol. 2017. PMID: 28070672 Free PMC article.

4

Loss of TMEM106B Ameliorates Lysosomal and Frontotemporal Dementia-Related Phenotypes in Progranulin-Deficient Mice.

Klein ZA, Takahashi H, Ma M, Stagi M, Zhou M, Lam TT, Strittmatter SM. Klein ZA, et al. Among authors: takahashi h. Neuron. 2017 Jul 19;95(2):281-296.e6. doi: 10.1016/j.neuron.2017.06.026. Neuron. 2017. PMID: 28728022 Free PMC article.

5

Liquid and Hydrogel Phases of PrP^C Linked to Conformation Shifts and Triggered by Alzheimer's Amyloid-β Oligomers.

Kostylev MA, Tuttle MD, Lee S, Klein LE, Takahashi H, Cox TO, Gunther EC, Zilm KW, Strittmatter SM. Kostylev MA, et al. Among authors: takahashi h. Mol Cell. 2018 Nov 1;72(3):426-443.e12. doi: 10.1016/j.molcel.2018.10.009. Epub 2018 Oct 25. Mol Cell. 2018. PMID: 30401430 Free PMC article.

6

Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.

Gunther EC, Smith LM, Kostylev MA, Cox TO, Kaufman AC, Lee S, Folta-Stogniew E, Maynard GD, Um JW, Stagi M, Heiss JK, Stoner A, Noble GP, Takahashi H, Haas LT, Schneekloth JS, Merkel J, Teran C, Naderi ZK, Supattapone S, Strittmatter SM. Gunther EC, et al. Among authors: takahashi h. Cell Rep. 2019 Jan 2;26(1):145-158.e8. doi: 10.1016/j.celrep.2018.12.021. Cell Rep. 2019. PMID: 30605671 Free PMC article.

7

Fyn kinase inhibition reduces protein aggregation, increases synapse density and improves memory in transgenic and traumatic Tauopathy.

Tang SJ, Fesharaki-Zadeh A, Takahashi H, Nies SH, Smith LM, Luo A, Chyung A, Chiasseu M, Strittmatter SM. Tang SJ, et al. Among authors: takahashi h. Acta Neuropathol Commun. 2020 Jul 1;8(1):96. doi: 10.1186/s40478-020-00976-9. Acta Neuropathol Commun. 2020. PMID: 32611392 Free PMC article.

8

Fronto-temporal dementia risk gene TMEM106B has opposing effects in different lysosomal storage disorders.

Perez-Canamas A, Takahashi H, Lindborg JA, Strittmatter SM. Perez-Canamas A, et al. Among authors: takahashi h. Brain Commun. 2020 Nov 16;3(1):fcaa200. doi: 10.1093/braincomms/fcaa200. eCollection 2021. Brain Commun. 2020. PMID: 33796852 Free PMC article.

9

Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.

Nies SH, Takahashi H, Herber CS, Huttner A, Chase A, Strittmatter SM. Nies SH, et al. Among authors: takahashi h. J Biol Chem. 2021 Oct;297(4):101159. doi: 10.1016/j.jbc.2021.101159. Epub 2021 Sep 2. J Biol Chem. 2021. PMID: 34480901 Free PMC article.

10

Transcriptomic taxonomy and neurogenic trajectories of adult human, macaque, and pig hippocampal and entorhinal cells.

Franjic D, Skarica M, Ma S, Arellano JI, Tebbenkamp ATN, Choi J, Xu C, Li Q, Morozov YM, Andrijevic D, Vrselja Z, Spajic A, Santpere G, Li M, Zhang S, Liu Y, Spurrier J, Zhang L, Gudelj I, Rapan L, Takahashi H, Huttner A, Fan R, Strittmatter SM, Sousa AMM, Rakic P, Sestan N. Franjic D, et al. Among authors: takahashi h. Neuron. 2022 Feb 2;110(3):452-469.e14. doi: 10.1016/j.neuron.2021.10.036. Epub 2021 Nov 18. Neuron. 2022. PMID: 34798047 Free PMC article.

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